ArticleFrontiers in genetics2016
The Genetic Contribution of West-African Ancestry to Protection against Central Obesity in African-American Men but Not Women: Results from the ARIC and MESA Studies.
Article in Frontiers in genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Erythroid Atypical Chemokine Receptor 1 Deficiency Aggravates Immune-Mediated Kidney Disease.Journal of the American Society of Nephrology : JASN · 2026Article
- Leveraging genetic ancestry to study health disparities.American journal of physical anthropology · 2021Article
- Racial, ethnic, and gender differences in obesity and body fat distribution: An All of Us Research Program demonstration project.PloS one · 2021Article
- Relationship between West African ancestry with lung cancer risk and survival in African Americans.Cancer causes & control : CCC · 2019Article
- The role of country of birth, and genetic and self-identified ancestry, in obesity susceptibility among African and Hispanic Americans.The American journal of clinical nutrition · 2019Article
- Genetic Ancestry Analysis Reveals Misclassification of Commonly Used Cancer Cell Lines.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Rapidly increasing prevalence of overweight and obesity in older Ghanaian adults from 2007-2015: Evidence from WHO-SAGE Waves 1 & 2.PloS one · 2019Article
- Criminal Justice Contact, Stressors, and Obesity-Related Health Problems Among Black Adults in the USA.Journal of racial and ethnic health disparities · 2018Article
- Indicators of abdominal size relative to height associated with sex, age, socioeconomic position and ancestry among US adults.PloS one · 2017Article
- The Metabolic Syndrome and Its Components in African-American Women: Emerging Trends and Implications.Frontiers in endocrinology · 2017Review
- Genomic ancestry and education level independently influence abdominal fat distributions in a Brazilian admixed population.PloS one · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Over 80% of African-American (AA) women are overweight or obese. A large racial disparity between AA and European-Americans (EA) in obesity rates exists among women, but curiously not among men. Although socio-economic and/or cultural factors may partly account for this race-by-sex interaction, the potential involvement of genetic factors has not yet been investigated. Among 2814 self-identified AA in the Atherosclerosis Risk in Communities study, we estimated each individual's degree of West-African genetic ancestry using 3437 ancestry informative markers. We then tested whether sex modifies the association between West-African genetic ancestry and body mass index (BMI), waist-circumference (WC), and waist-to-hip ratio (WHR), adjusting for income and education levels, and examined associations of ancestry with the phenotypes separately in males and females. We replicated our findings in the Multi-Ethnic Study of Atherosclerosis (n = 1611 AA). In both studies, we find that West-African ancestry is negatively associated with obesity, especially central obesity, among AA men, but not among AA women (pinteraction = 4.14 × 10(-5) in pooled analysis of WHR). In conclusion, our results suggest that the combination of male gender and West-African genetic ancestry is associated with protection against central adiposity, and suggest that the large racial disparity that exists among women, but not men, may be at least partly attributed to genetic factors.
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