ArticleFrontiers in psychology2016
Emotional Experience and Awareness of Self: Functional MRI Studies of Depersonalization Disorder.
Article in Frontiers in psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- A neurocognitive account of complex PTSD: self-modelling, affective dysregulation, and implications for MDMA-assisted and targeted psychotherapies.European journal of psychotraumatology · 2026Review
- Dissociative symptoms during the SARS-CoV-2 pandemic situation in mental health patients.Borderline personality disorder and emotion dysregulation · 2026Article
- A cross-sectional survey on depersonalization/derealization and meditation-induced alterations of the self.Scientific reports · 2026Article
- Presence Is Reality: Rethinking Virtual and Real-World Consciousness.Perspectives on psychological science : a journal of the Association for Psychological Science · 2026Article
- It Is Movement All the Way Down: Broken Rhythms and Embodied Selfhood in Depersonalization.Behavioral sciences (Basel, Switzerland) · 2025Article
- Altered Self-Referential-Related Brain Regions in Depersonalization-Derealization Disorder.Brain and behavior · 2025Article
- Dysfunctional large-scale brain networks in drug-naïve depersonalization-derealization disorder patients.BMC psychiatry · 2025Article
- Temporal depth in a coherent self and in depersonalization: theoretical model.Frontiers in psychology · 2025Article
- Dissociative Symptoms and Interoceptive Integration.Current topics in behavioral neurosciences · 2025Review
- Lifting the veil: probing altered visual perception in derealization.Neuroscience of consciousness · 2025Article
- Unraveling the brain dynamics of Depersonalization-Derealization Disorder: a dynamic functional network connectivity analysis.BMC psychiatry · 2024Article
- Examining the association between depersonalisation traits and the bodily self in waking and dreaming.Scientific reports · 2024Article
- A three-dimensional model of neural activity and phenomenal-behavioral patterns.Molecular psychiatry · 2024Review
- Pain suffering and the self. An active allostatic inference explanation.Neuroscience of consciousness · 2024Article
- What are the neural correlates of dissociative amnesia? A systematic review of the functional neuroimaging literature.Frontiers in psychiatry · 2023Review
- An Experimental Study of Subliminal Self-Face Processing in Depersonalization-Derealization Disorder.Brain sciences · 2022Article
- Potential Targets for Noninvasive Brain Stimulation on Depersonalization-Derealization Disorder.Brain sciences · 2022Article
- Clinical Manifestations of Body Memories: The Impact of Past Bodily Experiences on Mental Health.Brain sciences · 2022Article
- I overthink-Therefore I am not: An active inference account of altered sense of self and agency in depersonalisation disorder.Consciousness and cognition · 2022Article
- Zoomed out: digital media use and depersonalization experiences during the COVID-19 lockdown.Scientific reports · 2022Article
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Authors and funding
6 authors.
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Abstract
This paper presents functional MRI work on emotional processing in depersonalization disorder (DPD). This relatively neglected disorder is hallmarked by a disturbing change in the quality of first-person experience, almost invariably encompassing a diminished sense of self and an alteration in emotional experience such that the sufferer feels less emotionally reactive, with emotions experienced as decreased or "damped down," so that emotional life seems to lack spontaneity and subjective validity. Here we explored responses to emotive visual stimuli to examine the functional neuroanatomy of emotional processing in DPD before and after pharmacological treatment. We also employed concurrent skin conductance measurement as an index of autonomic arousal. In common with previous studies we demonstrated that in DPD, there is attenuated psychophysiological response to emotional material, reflected in altered patterns of (i) regional brain response, (ii) autonomic responses. By scanning participants before and after treatment we were able to build on previous findings by examining the changes in functional MRI response in patients whose symptoms had improved at time 2. The attenuation of emotional experience was associated with reduced activity of the insula, whereas clinical improvement in DPD symptoms was associated with increased insula activity. The insula is known to be implicated in interoceptive awareness and the generation of feeling states. In addition an area of right ventrolateral prefrontal cortex emerged as particularly implicated in what may be "top-down" inhibition of emotional responses. The relevance of these findings to the wider study of emotion, self-related processes, and interoception is discussed.
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