Evidence map›Paper›PMID 27313534›Full record

ReviewFrontiers in physiology2016

Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology.

Alison Barry, Owen Cronin, Aisling M Ryan, Brian Sweeney, Siew M Yap, Orna O'Toole, Andrew P Allen, Gerard Clarke, Ken D O'Halloran, Eric J Downer

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04545372 (Effect of Aerobic Exercises on Immune System in Patients With Multiple Sclerosis), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04545372 nacompletednot on this map

Effect of Aerobic Exercises on Immune System in Patients With Multiple Sclerosis

TypeinterventionalSponsorSouth Valley UniversityRan2015 to 2020Enrolled30ConditionsMultiple Sclerosis, Primary ProgressiveArmsaerobic exercise
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Observational
  5. Review
  6. To halt disease progression rehabilitation in MS should start early: No.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Observational
  17. Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Article
  18. Article
  19. Evaluating the Effectiveness of Physical Exercise Interventions in Persons Living With HIV: Overview of Systematic Reviews.AIDS education and prevention : official publication of the International Society for AIDS Education · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Alison BarryDepartment of Physiology, School of Medicine, University College Cork Cork, Ireland.
Owen CroninDepartment of Medicine, Cork University Hospital Cork, Ireland.
Aisling M RyanDepartment of Neurology, Cork University Hospital Cork, Ireland.
Brian SweeneyDepartment of Neurology, Cork University Hospital Cork, Ireland.
Siew M YapMercy University Hospital Cork, Ireland.
Orna O'TooleMercy University Hospital Cork, Ireland.
Andrew P AllenDepartment of Psychiatry and Neurobehavioral Science, APC Microbiome Institute, University College Cork Cork, Ireland.
Gerard ClarkeDepartment of Psychiatry and Neurobehavioral Science, APC Microbiome Institute, University College Cork Cork, Ireland.
Ken D O'HalloranDepartment of Physiology, School of Medicine, University College Cork Cork, Ireland.
Eric J DownerDepartment of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin Dublin, Ireland.
University College Cork · IECork University Hospital · IEMercy University Hospital · IETrinity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple Sclerosis (MS), an idiopathic progressive immune-mediated neurological disorder of the central nervous system (CNS), is characterized by recurrent episodes of inflammatory demyelination and consequent axonal deterioration. It accounts for functional deterioration and lasting disability among young adults. A body of literature demonstrates that physical activity counteracts fatigue and depression and may improve overall quality of life in MS patients. Furthermore, much data indicates that exercise ameliorates chronic neuroinflammation and its related pathologies by tipping cytokine profiles toward an anti-inflammatory signature. Recent data has focused on the direct impact of exercise training on the innate immune system by targeting toll-like receptors (TLRs), signaling pattern recognition receptors that govern the innate immune response, shedding light on the physiological role of TLRs in health and disease. Indeed, TLRs continue to emerge as players in the neuroinflammatory processes underpinning MS. This review will highlight evidence that physical activity and exercise are potential immunomodulatory therapies, targeting innate signaling mechanism(s) to modulate MS symptom development and progression.

Indexed as

cytokinesexerciseinnate immunityMultiple SclerosisneuroinflammationTLRs

Identifiers

PMID27313534
PMCPMC4889582
OpenAlexW2417172500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.