ArticleFrontiers in neural circuits2016
Homeostatic Plasticity Achieved by Incorporation of Random Fluctuations and Soft-Bounded Hebbian Plasticity in Excitatory Synapses.
Article in Frontiers in neural circuits, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Spine dynamics in the brain, mental disorders and artificial neural networks.Nature reviews. Neuroscience · 2021Review
- Dual-Component Structural Plasticity Mediated by αCaMKII Autophosphorylation on Basal Dendrites of Cortical Layer 2/3 Neurones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Non-scaling regulation of AMPA receptors in homeostatic synaptic plasticity.Neuropharmacology · 2019Article
- Intrinsic Spine Dynamics Are Critical for Recurrent Network Learning in Models With and Without Autism Spectrum Disorder.Frontiers in computational neuroscience · 2019Article
- Influence of Magnitude and Duration of Altered Gravity and Readaptation to 1 g on the Structure and Function of the Utricle in Toadfish,Frontiers in physiology · 2018Article
- Cooperative stochastic binding and unbinding explain synaptic size dynamics and statistics.PLoS computational biology · 2017Article
- Conduction Delay Learning Model for Unsupervised and Supervised Classification of Spatio-Temporal Spike Patterns.Frontiers in computational neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homeostatic plasticity is considered to maintain activity in neuronal circuits within a functional range. In the absence of homeostatic plasticity neuronal activity is prone to be destabilized because Hebbian plasticity mechanisms induce positive feedback change. Several studies on homeostatic plasticity assumed the existence of a process for monitoring neuronal activity on a time scale of hours and adjusting synaptic efficacy by scaling up and down. However, the underlying mechanism still remains unclear. Excitatory synaptic efficacy is associated with the size of the dendritic spine, and dendritic spine size fluctuates even after neuronal activity is silenced. These fluctuations could be a non-Hebbian form of synaptic plasticity that serves such a homeostatic function. This study proposed and analyzed a synaptic plasticity model incorporating random fluctuations and soft-bounded Hebbian plasticity at excitatory synapses, and found that the proposed model can prevent excessive changes in neuronal activity by scaling synaptic efficacy up and down. Soft-bounded Hebbian plasticity suppresses strong synapses, thereby scaling synapses down and preventing runaway excitation. Random fluctuations diffuse synaptic efficacy, thereby scaling synapses up and preventing neurons from falling silent. The proposed model acts as a form of homeostatic plasticity, regardless of neuronal activity monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.