ReviewNature and science of sleep2016
Circadian regulation of metabolic homeostasis: causes and consequences.
Review in Nature and science of sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05226650 (The Effect of Irregular Meal Pattern on Nitrogen Balance), which is not on this map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Irregular Meal Pattern on Nitrogen Balance: a Randomized Controlled Trial in Healthy Normal-weight Women
Who cites it
47 citing papers in PubMed, 78 citations in OpenAlex.
- Acute Beetroot Juice Supplementation Attenuates Morning-Associated Decrements in Supramaximal Exercise Performance in Trained Sprinters.International journal of environmental research and public health · 2021Trial
- Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans: a randomized controlled trial.Scientific reports · 2017Trial
- Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology · 2026Article
- The Co-Evolution of Sleep and Diet: Toward an Emerging Framework of Evolutionary Chrononutrition in Circadian-Metabolic Health.Nutrients · 2026Review
- Glucose is dynamically regulated by time of day in humans and Drosophila.PLoS biology · 2026Article
- Micro-arousals during REM and NREM sleep and lipid profile in obstructive sleep apnea: evidence from the shanghai sleep health study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Physiological rhythms and metabolic regulation: Shining light on skeletal muscle.Experimental physiology · 2025Review
- Circadian rhythms and gastrointestinal hormone-related appetite regulation.Current opinion in endocrinology, diabetes, and obesity · 2025Review
- Chrononutrition: Potential, Challenges, and Application in Managing Obesity.International journal of molecular sciences · 2025Review
- The associations between evening eating and quality of energy and macronutrients and obesity: the National Health and Nutrition Examination Survey (NHANES), 2003-2016.Nutrition journal · 2025Article
- Unraveling the complex relationship between night shift work and diabetes: exploring mechanisms and potential interventions.Frontiers in public health · 2025Review
- Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis over a day:night cycle.bioRxiv : the preprint server for biology · 2024Article
- Circadian gene signatures in the progression of obesity based on machine learning and Mendelian randomization analysis.Frontiers in nutrition · 2024Article
- Mitochondrial Dynamics in Pulmonary Hypertension.Biomedicines · 2023Review
- Clock genes regulate skeletal muscle energy metabolism through NAMPT/NADAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Insight into Potential Interactions of Thyroid Hormones, Sex Hormones and Their Stimulating Hormones in the Development of Non-Alcoholic Fatty Liver Disease.Metabolites · 2022Review
- Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes.International journal of molecular sciences · 2022Article
- Article
- Grape Seed Proanthocyanidins Mitigate the Disturbances Caused by an Abrupt Photoperiod Change in Healthy and Obese Rats.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Robust circadian rhythms in metabolic processes have been described in both humans and animal models, at the whole body, individual organ, and even cellular level. Classically, these time-of-day-dependent rhythms have been considered secondary to fluctuations in energy/nutrient supply/demand associated with feeding/fasting and wake/sleep cycles. Renewed interest in this field has been fueled by studies revealing that these rhythms are driven, at least in part, by intrinsic mechanisms and that disruption of metabolic synchrony invariably increases the risk of cardiometabolic disease. The objectives of this paper are to provide a comprehensive review regarding rhythms in glucose, lipid, and protein/amino acid metabolism, the relative influence of extrinsic (eg, neurohumoral factors) versus intrinsic (eg, cell autonomous circadian clocks) mediators, the physiologic roles of these rhythms in terms of daily fluctuations in nutrient availability and activity status, as well as the pathologic consequences of dyssynchrony.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.