Evidence map›Paper›PMID 27313467›Full record

ArticleOncoTargets and therapy2016

The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy.

Xu Feng, Kelei Zhu, Jinghua Liu, Jiang Chen, Jiacheng Tang, Yuelong Liang, Renan Jin, Xiao Liang, Xiujun Cai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  6. Review
  7. Article
  8. Article
  9. Semaphorin 3C as a Therapeutic Target in Prostate and Other Cancers.International journal of molecular sciences · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xu FengDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Kelei ZhuDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China; Department of General Surgery, Yinzhou People's Hospital, Ningbo, People's Republic of China.
Jinghua LiuDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Jiang ChenDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Jiacheng TangKey Lab of Surgery of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Yuelong LiangDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Renan JinDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Xiao LiangDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China.
Xiujun CaiDepartment of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, People's Republic of China; Key Lab of Surgery of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe ability to evaluate the prognosis of hepatocellular carcinoma (HCC) following hepatectomy using biological markers is of great importance. MATERIALS AND

methodsIn this study, we collected samples from 54 patients with HCC after hepatectomy. Immunohistochemistry was used to detect the expression of Sema3C and MFN2 in the HCC samples.

resultsImmunohistochemistry results showed that Sema3C and MFN2 co-expression was significantly associated with tumor size. In addition, a significant association between high Sema3C and low MFN2 levels and shorter overall survival was noted, when Sema3C and MFN2 co-expression was analyzed.

conclusionThe results suggest that the correlative expression level of Sema3C and MFN2 has a strong value in the prognosis of patients with HCC following hepatectomy.

Indexed as

hepatocellular carcinoma (HCC)MFN2prognosisSema3Csurvival analysis

Identifiers

PMID27313467
PMCPMC4892862
OpenAlexW2409430974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.