ArticleAyu
Antihyperglycemic activity of Albizzia lebbeck bark extract in streptozotocin-nicotinamide induced type II diabetes mellitus rats.
Article in Ayu. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus.Molecules (Basel, Switzerland) · 2022Review
- A Comprehensive Insight into the Phytochemical, Pharmacological Potential, and Traditional Medicinal Uses ofEvidence-based complementary and alternative medicine : eCAM · 2022Review
- Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats.Bioscience reports · 2021Article
- Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review.Oxidative medicine and cellular longevity · 2020Review
- Antidiabetic Potential of Medicinal Plants and Their Active Components.Biomolecules · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlbizzia lebbeck (L.) Benth. (Family - Leguminosae) extract is a proven mast cell stabilizing agent. Mast cells are involved in the inflammatory processes leading to the diabetes mellitus.
aimTo evaluate the effect of A. lebbeck against experimentally induced type 2 diabetes mellitus in rats. MATERIALS AND
methodFemale Sprague-Dawley rats were randomly allocated to six groups (n = 6). Diabetes was induced by single intraperitoneal injection of streptozotocin (50 mg/kg) given after 15 min of nicotinamide administration (110 mg/kg). Treatment with methanolic extract of A. lebbeck bark (MEAL) and metformin drug as standard was given for 21 days. Serum glucose (GLU) levels were measured on the 0 day and on 1(st), 7(th), 14(th) and 21(st) day after diabetes induction. After completion of study period, various biochemical parameters in serum such as - GLU, lipid profile, urea and creatinine were estimated. One-way analysis of variance followed with post-hoc Dunnett's test was used to analyse the data. Statistical significance for the values was set at P< 0.05.
resultsMEAL significantly decreased the level of serum GLU, creatinine, urea, cholesterol, triglycerides, low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol and increased high-density lipoprotein levels.
conclusionA. lebbeck bark extract showed antihyperglycaemic activity along with antihyperlipidemic effect.
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