ReviewBehavioural neurology2016
Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives.
Review in Behavioural neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Experimentally evoked pain in Alzheimer's disease.Journal of the American Association of Nurse Practitioners · 2021Pooled it
- Association of chronic pain and analgesic use with the risks of Parkinson's and Alzheimer's disease.GeroScience · 2026Article
- Diphenyleneiodonium exhibits protective effects against both nociception and gastrointestinal inflammation in vivo.Inflammopharmacology · 2026Article
- Perineural Invasion Exhibits Traits of Neurodegeneration.Journal of dental research · 2025Article
- Dyadic Comparison of Pain and Stress in Alzheimer's Disease and Caregivers.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025Article
- Determination of soluble tumor necrosis factor receptor II and secretory immunoglobulin A in saliva of patients with dementia.European archives of psychiatry and clinical neuroscience · 2024Article
- The interactive effects of different exercises and hawthorn consumption on the pain threshold of TMT-induced Alzheimer male rats.The journal of physiological sciences : JPS · 2024Article
- Neurodegeneration in Cognitive Impairment and Mood Disorders for Experimental, Clinical and Translational Neuropsychiatry.Biomedicines · 2024Article
- Trends in pain undertreatment among lung cancer patients at the EOL: Analysis of urban city medical insurance data in China.Thoracic cancer · 2024Article
- Article
- Pain Management at the End of Life in the Emergency Department: A Narrative Review of the Literature and a Practical Clinical Approach.Journal of clinical medicine · 2023Review
- Pain, Opioid Analgesics, and Cognition: A Conceptual Framework in Older Adults.Pain medicine (Malden, Mass.) · 2023Article
- Effectiveness and Therapeutic Mechanism of Pharmacopuncture for Pain in Parkinson's Disease: A Study Protocol for a Pilot Pragmatic Randomized, Assessor-Blinded, Usual Care-Controlled, Three-Arm Parallel Trial.International journal of environmental research and public health · 2023Article
- Pain in Huntington's disease and its potential mechanisms.Frontiers in aging neuroscience · 2023Review
- Synthesis, Characterization and Biological Evaluation of Benzothiazole-Isoquinoline Derivative.Molecules (Basel, Switzerland) · 2022Article
- Opioids in the Elderly Patients with Cognitive Impairment: A Narrative Review.Pain and therapy · 2022Review
- Neural basis of affective touch and pain: A novel model suggests possible targets for pain amelioration.Journal of neuropsychology · 2022Review
- Persistence of pain and cognitive impairment in older adults.Journal of the American Geriatrics Society · 2022Article
- Increased pain unpleasantness and pain-related fMRI activation in the periaqueductal gray in Alzheimer's disease.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Sleep, Pain, and Neurodegeneration: A Mendelian Randomization Study.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. Many of these patients complain of painful symptoms though their origin is variable, and their presence is frequently not considered in the treatment guidelines, leaving their management to the decision of the clinicians alone. However, studies focusing on pain frequency in such disorders suggest a high prevalence of pain in selected populations from 38 to 75% in AD, 40% to 86% in PD, and 19 to 85% in MND. The methods of pain assessment vary between studies so the type of pain has been rarely reported. However, a prevalent nonneuropathic origin of pain emerged for MND and PD. In AD, no data on pain features are available. No controlled therapeutic trials and guidelines are currently available. Given the relevance of pain in neurodegenerative disorders, the comprehensive understanding of mechanisms and predisposing factors, the application and validation of specific scales, and new specific therapeutic trials are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.