Evidence map›Paper›PMID 27313335›Full record

ArticleDisease markers2016

Immunohistochemical Expression of VEGF and Podoplanin in Uterine Cervical Squamous Intraepithelial Lesions.

Patrícia Napoli Belfort-Mattos, Gustavo Rubino de Azevedo Focchi, Julisa Chamorro Lascasas Ribalta, Tatiana Megale De Lima, Carmen Regina Nogueira Carvalho, Fernanda Kesselring Tso, Neila Maria De Góis Speck

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Cervical Carcinoma: Oncobiology and Biomarkers.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Patrícia Napoli Belfort-MattosGynecological Disease Prevention Nucleus (NUPREV), Department of Gynecology, Federal University of São Paulo, UNIFESP/EPM, 380 Borges Lagoa Street, 04038-000 São Paulo, SP, Brazil.
Gustavo Rubino de Azevedo FocchiDepartment of Pathology, Federal University of São Paulo, UNIFESP/EPM, 740 Botucatu Street, 04023-062 São Paulo, SP, Brazil.
Julisa Chamorro Lascasas RibaltaGynecological Disease Prevention Nucleus (NUPREV), Department of Gynecology, Federal University of São Paulo, UNIFESP/EPM, 380 Borges Lagoa Street, 04038-000 São Paulo, SP, Brazil.
Tatiana Megale De LimaGynecological Disease Prevention Nucleus (NUPREV), Department of Gynecology, Federal University of São Paulo, UNIFESP/EPM, 380 Borges Lagoa Street, 04038-000 São Paulo, SP, Brazil.
Carmen Regina Nogueira CarvalhoGynecological Disease Prevention Nucleus (NUPREV), Department of Gynecology, Federal University of São Paulo, UNIFESP/EPM, 380 Borges Lagoa Street, 04038-000 São Paulo, SP, Brazil.
Fernanda Kesselring TsoGynecological Disease Prevention Nucleus (NUPREV), Department of Gynecology, Federal University of São Paulo, UNIFESP/EPM, 380 Borges Lagoa Street, 04038-000 São Paulo, SP, Brazil.
Neila Maria De Góis SpeckGynecological Disease Prevention Nucleus (NUPREV), Department of Gynecology, Federal University of São Paulo, UNIFESP/EPM, 380 Borges Lagoa Street, 04038-000 São Paulo, SP, Brazil.
Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

VEGF and podoplanin (PDPN) have been identified as angiogenesis and/or lymphangiogenesis regulators and might be essential to restrict tumor growth, progression, and metastasis. In the present study, we evaluate the association between the expression of these markers and CIN grade. Immunohistochemistry was performed in 234 uterine cervical samples using conventional histologic sections or TMA with the monoclonal antibodies to VEGF (C-1 clone) and podoplanin (D2-40 clone). Positive-staining rates of VEGF in 191 CIN specimens were significantly associated with histological grade (P < 0.001). Negative and/or focal immunostaining for PDPN were more frequent in CIN 3 (P = 0.016). We found that patients with CIN 3 more frequently had strong and more diffuse staining for VEGF and diminished staining for PDPN (P = 0.018). Strong and more diffuse VEGF immunoexpressions in CIN 2 and CIN 3 were detected when compared to CIN 1. Negative and/or focal PDPN immunoexpression appear to be more frequent in CIN 3. Moderate to strong VEGF expression may be a tendency among patients with high-grade lesions and diminished PDPN expression.

Indexed as

AdultBiomarkers, TumorCase-Control StudiesCross-Sectional StudiesFemaleFollow-Up StudiesHumansImmunoenzyme TechniquesMembrane GlycoproteinsNeoplasm StagingPodoplaninPrognosisRetrospective StudiesSquamous Intraepithelial Lesions of the CervixUterine Cervical DysplasiaUterine Cervical NeoplasmsBiomarkers, TumorMembrane GlycoproteinsPDPN protein, humanPodoplaninVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID27313335
PMCPMC4895031
OpenAlexW2408447160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.