Evidence map›Paper›PMID 27313241›Full record

ArticlePhysical therapy2016

Effects of Locomotor Exercise Intensity on Gait Performance in Individuals With Incomplete Spinal Cord Injury.

Kristan A Leech, Catherine R Kinnaird, Carey L Holleran, Jennifer Kahn, T George Hornby

2 registry-linked trialsAbstract read
In one paragraph

Article in Physical therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06137443 nacompletednot on this mapstarted 2022, after this paper: background citation

Enhancing Balance and Mobility in Incomplete Spinal Cord Injury With an Overground Gait Trainer

TypeinterventionalSponsorAnkara City Hospital BilkentRan2022 to 2022Enrolled5ConditionsSpinal Cord Injuries, Walking, DifficultyArmsBalance Training
NCT06137456 nacompletednot on this mapstarted 2022, after this paper: background citation

First Report of a New Exoskeleton in Incomplete Spinal Cord Injury: FreeGait®

TypeinterventionalSponsorAnkara City Hospital BilkentRan2022 to 2023Enrolled14ConditionsSpinal Cord Injuries, Walking, DifficultyArmsExoskeletal robotic therapy for walking., Conventional exercise therapy
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Gait analysis methods in people with spinal cord injury: a systematic review.Journal of neuroengineering and rehabilitation · 2026
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  20. Use of Pelvic Corrective Force With Visual Feedback Improves Paretic Leg Muscle Activities and Gait Performance After Stroke.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kristan A LeechK.A. Leech, PT, DPT, PhD, Interdepartmental Neuroscience Program, Northwestern University, Chicago, Illinois, and Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, Illinois.
Catherine R KinnairdC.R. Kinnaird, ME, Sensory Motor Performance Program, Rehabilitation Institute of Chicago.
Carey L HolleranC.L. Holleran, PT, MPT, DHS, Sensory Motor Performance Program, Rehabilitation Institute of Chicago.
Jennifer KahnJ. Kahn, PT, DPT, Sensory Motor Performance Program, Rehabilitation Institute of Chicago.
T George HornbyT.G. Hornby, PT, PhD, Interdepartmental Neuroscience Program, Northwestern University, Chicago, Illinois; Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, Illinois; and Department of Physical Medicine and Rehabilitation, Northwestern University, 345 E Superior St, Room 1382, Chicago, IL 60611 (USA). g-hornby@northwestern.edu.

Funding

Sympathetic-somatomotor coupling in human SCIR01NS079751 · NINDS · MARQUETTE UNIVERSITY · PI HORNBY, THOMAS GEORGE, SCHMIT, BRIAN D · 2013 to 2017
$1.6M
Behavioral and molecular responses to high-intensity exercise in humans with iSCIF31NS084723 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEECH, KRISTAN A. · 2013 to 2015
$62k
NINDS NIH HHS F31 NS084723NINDS NIH HHS R01 NS079751
6 · The paper itself

Abstract

backgroundHigh-intensity stepping practice may be a critical component to improve gait following motor incomplete spinal cord injury (iSCI). However, such practice is discouraged by traditional theories of rehabilitation that suggest high-intensity locomotor exercise degrades gait performance. Accordingly, such training is thought to reinforce abnormal movement patterns, although evidence to support this notion is limited.

objectiveThe purposes of this study were: (1) to evaluate the effects of short-term manipulations in locomotor intensity on gait performance in people with iSCI and (2) to evaluate potential detrimental effects of high-intensity locomotor training on walking performance.

designA single-day, repeated-measures, pretraining-posttraining study design was used.

methodsNineteen individuals with chronic iSCI performed a graded-intensity locomotor exercise task with simultaneous collection of lower extremity kinematic and electromyographic data. Measures of interest were compared across intensity levels of 33%, 67%, and 100% of peak gait speed. A subset of 9 individuals participated in 12 weeks of high-intensity locomotor training. Similar measurements were collected and compared between pretraining and posttraining evaluations.

resultsThe results indicate that short-term increases in intensity led to significant improvements in muscle activity, spatiotemporal metrics, and joint excursions, with selected improvements in measures of locomotor coordination. High-intensity locomotor training led to significant increases in peak gait speed (0.64-0.80 m/s), and spatiotemporal and kinematic metrics indicate a trend for improved coordination. LIMITATIONS: Measures of gait performance were assessed during treadmill ambulation and not compared with a control group. Generalizability of these results to overground ambulation is unknown.

conclusionsHigh-intensity locomotor exercise and training does not degrade, but rather improves, locomotor function and quality in individuals with iSCI, which contrasts with traditional theories of motor dysfunction following neurologic injury.

Indexed as

AdolescentAdultAgedAnkle JointBiomechanical PhenomenaElectromyographyExercise TherapyFemaleHip JointHumansKnee JointLower ExtremityMaleMiddle AgedMuscle, SkeletalRange of Motion, Articular

Identifiers

PMID27313241
PMCPMC5131185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.