ArticleAmerican journal of epidemiology2016
Comparison of Puff Volume With Cigarettes per Day in Predicting Nicotine Uptake Among Daily Smokers.
Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Relationships Between the Nicotine Metabolite Ratio and Laboratory Assessments of Smoking Reinforcement and Craving Among Adults in a Smoking Cessation Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Trial
- Article
- Randomized crossover clinical studies to assess abuse liability and nicotine pharmacokinetics of Velo Oral Nicotine pouches.Frontiers in pharmacology · 2025Article
- Nicotinic Receptor Alpha-5 Subunit Gene Polymorphism is Associated With Heavy Smoking Under a Range of Nicotine Dosing Conditions.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Switching people who smoke to unfiltered cigarettes: Effects on smoking topography.Addictive behaviors reports · 2024Article
- Diurnal variability of cortisol in the Pennsylvania adult smoking study: Exploration of association with nicotine intake.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Pharmacokinetic differences in nicotine and nicotine salts mediate reinforcement-related behavior: an animal model study.Frontiers in neuroscience · 2023Article
- Smoking intensity and urinary nicotine metabolites by socioeconomic status in the Heinz Nixdorf Recall study.BMC public health · 2022Article
- Characterizing nicotine exposure among a community sample of non-daily smokers in the United States.BMC public health · 2021Article
- Comparing video observation to electronic topography device as a method for measuring cigarette puffing behavior.Drug and alcohol dependence · 2021Article
- Changes in salivary proteome before and after cigarette smoking in smokers compared to sham smoking in nonsmokers: A pilot study.Tobacco induced diseases · 2021Article
- Household Smoking Restrictions, Time to First Cigarette and Tobacco Dependence.Journal of smoking cessation · 2021Article
- Addressing the challenges of E-cigarette safety profiling by assessment of pulmonary toxicological response in bronchial and alveolar mucosa models.Scientific reports · 2020Article
- A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States.Drug and alcohol dependence · 2020Article
- Pesticides residues in tobacco smoke: risk assessment study.Environmental monitoring and assessment · 2020Article
- Effects of Nicotine Metabolic Rate on Cigarette Reinforcement.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- The Use of the Nicotine Metabolite Ratio as a Biomarker to Personalize Smoking Cessation Treatment: Current Evidence and Future Directions.Cancer prevention research (Philadelphia, Pa.) · 2020Review
- Lung function decline in former smokers and low-intensity current smokers: a secondary data analysis of the NHLBI Pooled Cohorts Study.The Lancet. Respiratory medicine · 2020Article
- Time to first cigarette of the day and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in adult regular and non-daily smokers: (NHANES) 2007-10.Regulatory toxicology and pharmacology : RTP · 2019Article
- The effects of hookah/waterpipe smoking on general health and the cardiovascular system.Environmental health and preventive medicine · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The role of inhalation behaviors as predictors of nicotine uptake was examined in the Pennsylvania Adult Smoking Study (2012-2014), a study of 332 adults whose cigarette smoking was measured in a naturalistic environment (e.g., at home) with portable handheld topography devices. Piecewise regression analyses showed that levels of salivary cotinine, trans-3'-hydroxycotinine, and total salivary nicotine metabolites (cotinine + trans-3'-hydroxycotinine) increased linearly up to a level of about 1 pack per day (20 cigarettes per day (CPD)) (P < 0.01). Total daily puff volume (TDPV; in mL) (P < 0.05) and total daily number of puffs (P < 0.05), but not other topographical measures, increased linearly with CPD up to a level of about 1 pack per day. The mean level of cotinine per cigarette did not change above 20 CPD and was 36% lower in heavy smokers (≥20 CPD) than in lighter smokers (<20 CPD) (15.6 ng/mL vs. 24.5 ng/mL, respectively; P < 0.01). Mediation models showed that TDPV accounted for 43%-63% of the association between CPD and nicotine metabolites for smokers of <20 CPD. TDPV was the best predictor of nicotine metabolite levels in light-to-moderate smokers (1-19 CPD). In contrast, neither CPD, total daily number of puffs, nor TDPV predicted nicotine metabolite levels above 20 CPD (up to 40 CPD). Finally, although light smokers are traditionally considered less dependent on nicotine, these findings suggest that they are exposed to more nicotine per cigarette than are heavy smokers due to more frequent, intensive puffing.
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Registered trials
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