ArticleScientific reports2016
Two Figla homologues have disparate functions during sex differentiation in half-smooth tongue sole (Cynoglossus semilaevis).
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 41 citations in OpenAlex.
- Molecular Characterization, Expression Pattern, DNA Methylation and Gene Disruption ofAnimals : an open access journal from MDPI · 2024Article
- Master-Key Regulators of Sex Determination in Fish and Other Vertebrates-A Review.International journal of molecular sciences · 2023Review
- Identification and Expression Pattern ofAnimals : an open access journal from MDPI · 2022Article
- Absence ofInternational journal of molecular sciences · 2022Article
- A Potential Role of the Translation Elongation FactorAnimals : an open access journal from MDPI · 2022Article
- Identification of global alternative splicing and sex-specific splicing via comparative transcriptome analysis of gonads of Chinese tongue sole (Zoological research · 2022Article
- Article
- Sex Determination and Differentiation in Teleost: Roles of Genetics, Environment, and Brain.Biology · 2021Review
- A simple and rapid method for fish sex identification based on recombinase-aided amplification and its use in Cynoglossus semilaevis.Scientific reports · 2021Article
- Seminal Plasma Exosomes: Promising Biomarkers for Identification of Male and Pseudo-Males in Cynoglossus semilaevis.Marine biotechnology (New York, N.Y.) · 2019Article
- The autosomal Gsdf gene plays a role in male gonad development in Chinese tongue sole (Cynoglossus semilaevis).Scientific reports · 2018Article
- Article
- Locus Mapping, Molecular Cloning, and Expression Analysis of rps6kb2, a Novel Metamorphosis-Related Gene in Chinese Tongue Sole (Cynoglossus semilaevis).Marine biotechnology (New York, N.Y.) · 2017Article
- Identification of exosomes and its signature miRNAs of male and female Cynoglossus semilaevis.Scientific reports · 2017Article
- Identification and analysis of the β-catenin1 gene in half-smooth tongue sole (Cynoglossus semilaevis).PloS one · 2017Article
- Molecular cloning and expression analysis of the aqp1aa gene in half-smooth tongue sole (Cynoglossus semilaevis).PloS one · 2017Article
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10 authors at 3 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Figla is a germ-cell-specific transcription factor associated with ovary development and differentiation. In vertebrates, one transcriptional form of Figla is commonly found. However, besides the common form of this gene (named Figla_tv1), a new transcriptional form (named Figla_tv2) was identified in half-smooth tongue sole (Cynoglossus semilaevis). The full-length cDNA of Figla_tv1 was 1057 bp long with a 591-bp open reading frame encoding a predicted 196 amino acid protein, while Figla_tv2 encoded a 125 amino acid protein. Figla_tv1 and Figla_tv2 expression in various tissues was detected by qRT-PCR. Figla_tv1 was expressed mainly in ovary, skin and liver, while Figla_tv2 was expressed in all examined tissues. In the gonads, Figla_tv1 was expressed in ovary, while Figla_tv2 was predominately expressed in testis of pseudomales. Further, in situ hybridization located Figla_tv1 only in oocytes and Figla_tv2 mainly in germ cells of pseudomale testis. After knocking down Figla_tv2 in a pseudomale testis cell line, the expression of two steroid hormone-encoding genes, StAR and P450scc, was significantly up-regulated (P < 0.05). Our findings suggest that Figla_tv1 has a conserved function in folliculogenesis, as in other vertebrates, and that Figla_tv2 may have a role in the spermatogenesis of pseudomales by regulating the synthesis and metabolism of steroid hormones.
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