ArticleAngewandte Chemie (International ed. in English)2016
Palladium Catalysis Enables Benzylation of α,α-Difluoroketone Enolates.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Electricity-Controlled Divergent Synthesis of CFJACS Au · 2026Article
- Cobalt-catalyzed decarboxylative difluoroalkylation of nitrophenylacetic acid salts.Chemical science · 2023Article
- Palladium-Catalyzed Dearomatization of Benzothiophenes: Isolation and Functionalization of a Discrete Dearomatized Intermediate.Synthesis · 2023Article
- Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs.Molecules (Basel, Switzerland) · 2022Article
- Decarbonylative Fluoroalkylation at Palladium(II): From Fundamental Organometallic Studies to Catalysis.Journal of the American Chemical Society · 2021Article
- Nickel-Catalyzed Decarbonylative Synthesis of Fluoroalkyl Thioethers.ACS catalysis · 2020Article
- Organophotoredox/palladium dual catalytic decarboxylative CspChemical science · 2020Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
A palladium-catalyzed decarboxylative benzylation reaction of α,α-difluoroketone enolates is reported, in which the key C(α)-C(sp(3) ) bond is generated by reductive elimination from a palladium intermediate. The transformation provides convergent access to α-benzyl-α,α-difluoroketone-based products, and should be useful for accessing biological probes.
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