ArticleEnvironmental health : a global access science source2016
Toddler temperament and prenatal exposure to lead and maternal depression.
Article in Environmental health : a global access science source, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Prenatal psychological distress and neurodevelopmental trajectories in the first 3 years: a systematic review.BMJ open · 2025Pooled it
- An interpretable machine learning model predicts the interactive and cumulative risks of different environmental chemical exposures on depression.Translational psychiatry · 2025Article
- Infant cognitive home environment as a moderator for the association of prenatal lead on child language.Neurotoxicology · 2025Article
- Associations of temperament, family functioning with loneliness trajectories in patients with breast cancer: a longitudinal observational study.BMC psychology · 2025Observational
- Individualized support for breastfeeding in a case of elevated blood lead levels: A case report.Toxicology reports · 2024Article
- Chemical and non-chemical stressors in a postpartum cohort through wristband and self report data: Links between increased chemical burden, economic, and racial stress.Environment international · 2024Article
- Postnatal nighttime light exposure and infant temperament at age 12 months: mediating role of genus Akkermansia.European child & adolescent psychiatry · 2024Article
- Individual and joint effects of prenatal PMEnvironmental research · 2024Article
- Associations between mother's depressive symptoms during pregnancy and newborn's brain functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Convergent neural correlates of prenatal exposure to air pollution and behavioral phenotypes of risk for internalizing and externalizing problems: Potential biological and cognitive pathways.Neuroscience and biobehavioral reviews · 2022Review
- Lead exposure and serum metabolite profiles in pregnant women in Mexico City.Environmental health : a global access science source · 2021Article
- Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes.Environment international · 2021Article
- Prenatal metal mixtures and sex-specific infant negative affectivity.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Cognitive Impairment Induced by Lead Exposure during Lifespan: Mechanisms of Lead Neurotoxicity.Toxics · 2021Review
- Prenatal PMNeurotoxicology · 2020Article
- Can broad-spectrum multinutrients treat symptoms of antenatal depression and anxiety and improve infant development? Study protocol of a double blind, randomized, controlled trial (the 'NUTRIMUM' trial).BMC pregnancy and childbirth · 2020Article
- Combined Impacts of Prenatal Environmental Exposures and Psychosocial Stress on Offspring Health: Air Pollution and Metals.Current environmental health reports · 2020Review
- Environmental mixtures and children's health: identifying appropriate statistical approaches.Current opinion in pediatrics · 2020Review
- Using the delayed spatial alternation task to assess environmentally associated changes in working memory in very young children.Neurotoxicology · 2020Article
- Blood manganese levels during pregnancy and postpartum depression: A cohort study among women in Mexico.Neurotoxicology · 2020Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTemperament is a psychological construct that reflects both personality and an infant's reaction to social stimuli. It can be assessed early in life and is stable over time Temperament predicts many later life behaviors and illnesses, including impulsivity, emotional regulation and obesity. Early life exposure to neurotoxicants often results in developmental deficits in attention, social function, and IQ, but environmental predictors of infant temperament are largely unknown. We propose that prenatal exposure to both chemical and non-chemical environmental toxicants impacts the development of temperament, which can itself be used as a marker of risk for maladaptive neurobehavior in later life. In this study, we assessed associations among prenatal and early life exposure to lead, mercury, poverty, maternal depression and toddler temperament.
methodsA prospective cohort of women living in the Mexico City area were followed longitudinally beginning in the second trimester of pregnancy. Prenatal exposure to lead (blood, bone), mercury, and maternal depression were assessed repeatedly and the Toddler Temperament Scale (TTS) was completed when the child was 24 months old. The association between each measure of prenatal exposure and performance on individual TTS subscales was evaluated by multivariable linear regression. Latent profile analysis was used to classify subjects by TTS performance. Multinomial regression models were used to estimate the prospective association between prenatal exposures and TTS performance.
results500 mother-child pairs completed the TTS and had complete data on exposures and covariates. Three latent profiles were identified and categorized as predominantly difficult, intermediate, or easy temperament. Prenatal exposure to maternal depression predicted increasing probability of difficult toddler temperament. Maternal bone lead, a marker of cumulative exposure, also predicted difficult temperament. Prenatal lead exposure modified this association, suggesting that joint exposure in pregnancy to both was most toxic.
conclusionsMaternal depression predicts difficult temperament and concurrent prenatal exposure to maternal depression and lead predicts a more difficult temperament phenotype in 2 year olds. The role of temperament as an intermediate variable in the path from prenatal exposures to neurobehavioral deficits and other health effects deserves further study.
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