Evidence map›Paper›PMID 27312820›Full record

ArticleThe Journal of allergy and clinical immunology2017

Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence.

Frederick J Rubner, Daniel J Jackson, Michael D Evans, Ronald E Gangnon, Christopher J Tisler, Tressa E Pappas, James E Gern, Robert F Lemanske

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 5 pooled it
19.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 5 syntheses or guidelines pooled it, 251 citations in OpenAlex.

  1. Pooled it
  2. Vaccines for the common cold.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Prednisolone for the first rhinovirus-induced wheezing and 4-year asthma risk: A randomized trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2017
    Trial
  10. Allergic sensitization and respiratory infection in infancy-Too early for two-hits on lung function?Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  11. Article
  12. Article
  13. Viral and Host-Related Factors in the Nasal Inflammatory Response to Critical Bronchiolitis in Infants and Children.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026
    Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Beyond respiratory syncytial virus and rhinovirus: The other viral respiratory bandits.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Review

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Frederick J RubnerDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wis; Department of Medicine, University of Wisconsin-Madison, Madison, Wis.
Daniel J JacksonDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wis. Electronic address: djj@medicine.wisc.edu.
Michael D EvansDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wis.
Ronald E GangnonDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wis; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, Wis.
Christopher J TislerDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wis.
Tressa E PappasDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wis.
James E GernDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wis; Department of Medicine, University of Wisconsin-Madison, Madison, Wis.
Robert F LemanskeDepartment of Pediatrics, University of Wisconsin-Madison, Madison, Wis; Department of Medicine, University of Wisconsin-Madison, Madison, Wis.
University of Wisconsin–Madison · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BOCHKOV, YURY A · 2002 to 2017
$31.3M
NCATS NIH HHS UL1 TR000427NHLBI NIH HHS P01 HL070831
6 · The paper itself

Abstract

backgroundEarly life rhinovirus (RV) wheezing illnesses and aeroallergen sensitization increase the risk of asthma at school age. Whether these remain risk factors for the persistence of asthma out to adolescence is not established.

objectiveWe sought to define the relationships among specific viral illnesses and the type and timing of aeroallergen sensitization with the persistence of asthma into adolescence.

methodsA total of 217 children were followed prospectively from birth to age 13 years. The etiology and timing of viral wheezing illnesses during the first 3 years of life were assessed along with patterns of allergen sensitization. The associations between viral wheezing illnesses, presence and pattern of aeroallergen sensitization, and asthma diagnosis at age 13 years were evaluated.

resultsWhen adjusted for all viral etiologies, wheezing with RV (odds ratio = 3.3; 95% CI, 1.5-7.1), but not respiratory syncytial virus (odds ratio = 1.0; 95% CI, 0.4-2.3), was associated with asthma at age 13 years. Age of aeroallergen sensitization also influenced asthma risk; 65% of children sensitized by age 1 year had asthma at age 13 years, compared with 40% of children not sensitized at age 1 year but sensitized by age 5 years, and 17% of children not sensitized at age 5 years. Early life aeroallergen sensitization and RV wheezing had additive effects on asthma risk at adolescence.

conclusionsIn a high-risk birth cohort, the persistence of asthma at age 13 years was most strongly associated with outpatient wheezing illnesses with RV and aeroallergen sensitization in early life.

Indexed as

AdolescentAge FactorsAge of OnsetAllergensAsthmaChildChild, PreschoolFemaleFollow-Up StudiesHumansImmunizationInfantInfant, NewbornMalePicornaviridae InfectionsProspective StudiesAllergensallergic sensitizationasthmarespiratory syncytial virusRhinovirus

Identifiers

PMID27312820
PMCPMC5104680
OpenAlexW2366983981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.