SynthesisJournal of the American Heart Association2016
Long-Term Survival of Individuals Born With Congenital Heart Disease: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 67 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Survival of children with rare structural congenital anomalies: a multi-registry cohort study.Orphanet journal of rare diseases · 2022Pooled it
- Exercise Capacity in Children and Adolescents With Congenital Heart Disease: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Physical activity interventions for people with congenital heart disease.The Cochrane database of systematic reviews · 2020Pooled it
- Long-term survival of children born with congenital anomalies: A systematic review and meta-analysis of population-based studies.PLoS medicine · 2020Pooled it
- Children Born with Congenital Heart Defects and Growth Restriction at Birth: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Mental Health Among Parents of Children With Critical Congenital Heart Defects: A Systematic Review.Journal of the American Heart Association · 2017Pooled it
- Health Care Utilization in Adults With Congenital Heart Disease: Population-Based Findings.Birth defects research · 2026Article
- Machine Learning Model for Predicting Postoperative Complications in Pediatric Simple Congenital Heart Disease with Right Vertical Infra-Axillary Incision.Journal of cardiovascular development and disease · 2026Article
- A bibliometric analysis of the top 100 most-cited articles in interventional cardiology: trends, authors, journals, origins, and gender representation.Annals of medicine and surgery (2012) · 2026Review
- Prenatal diagnostic value of medium-coverage WGS and clinical Exome sequencing in fetal congenital heart disease.Future science OA · 2025Article
- Neighborhood Income Disparities in Unplanned Hospital Admission and In-Hospital Outcomes Among Children with Congenital Heart Disease.Pediatric cardiology · 2025Article
- Preclinical Evaluation of a Growth-Accommodating Transcatheter Pulmonary Valve System for Young Children.Journal of the American Heart Association · 2025Article
- Body image of men and women with congenital heart disease over a 15 years observational period.Scientific reports · 2025Article
- Chromosomal analysis and short-term outcome of prenatally diagnosed congenital heart disease.Scientific reports · 2025Article
- Global, regional, and national burdens of congenital heart anomalies from 1990 to 2021, and projections to 2050.Frontiers in pediatrics · 2025Article
- Evaluating Long-Term Outcomes of Children Undergoing Surgical Treatment for Congenital Heart Disease for National Audit in England and Wales.Journal of the American Heart Association · 2024Article
- Survival of Children With Critical Congenital Heart Defects in the National Birth Defects Prevention Study.Birth defects research · 2024Article
- Review
- Incidence and predictors of mortality among neonates with congenital heart disease in Ethiopia: a retrospective cohort study.BMC pediatrics · 2024Article
- Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedLong-Term Survival of Individuals Born With Congenital Heart Disease: A Systematic Review and Meta-Analysis.2016 · Best, Katie E [corrected to Best, Kate E]
Authors and funding
2 authors.
Funding
Abstract
backgroundEstimates of long-term survival are required to adequately assess the variety of health and social services required by those with congenital heart disease (CHD) throughout their lives. METHODS AND
resultsMedline, Embase, and Scopus were searched from inception to June 2015 using MeSH headings and keywords. Population-based studies that ascertained all persons born with CHD within a predefined area and reported survival estimates at ≥5 years were included. Unadjusted survival estimates for each CHD subtype at ages 1 year, 5 years, 10 years, and so forth were extracted. Pooled survival estimates for each age were calculated using meta-analyses. Metaregression was performed to examine the impact of study period on survival. Of 7840 identified articles, 16 met the inclusion criteria. Among those with CHD, pooled 1-year survival was 87.0% (95% CI 82.1-91.2), pooled 5-year survival was 85.4% (95% CI 79.4-90.5), and pooled 10-year survival was 81.4% (95% CI 73.8-87.9). There was significant heterogeneity of survival estimates among articles (P<0.001 for 1-, 5-, and 10-year survival). A more recent study period was significantly associated with greater survival at ages 1 year (P=0.047), 5 years (P=0.013), and 10 years (P=0.046). Survival varied by CHD subtype, with 5-year survival being greatest for those with ventricular septal defect (96.3%, 95% CI 93.7-98.2) and lowest for those with hypoplastic left heart (12.5%, 95% CI 0.0-41.4).
conclusionsAmong persons with CHD, the mortality rate is greatest during the first year of life; however, this systematic review and meta-analysis showed that survival decreases gradually after infancy and into adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.