ArticleFood & nutrition research2016
Antimicrobial, antioxidant, and antitumor activity of epsilon-poly-L-lysine and citral, alone or in combination.
Article in Food & nutrition research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- pH-Responsive Isoprenoid-Antitumoral Polymer Conjugates for Superior Drug Loading via Self-Assembly and Endosomal-Targeted Anticancer Activity.ChemMedChem · 2026Article
- Poly-basic peptides and polymers as new drug candidates against Plasmodium falciparum.Malaria journal · 2024Article
- Design of three-component essential oil extract mixture from Cymbopogon flexuosus, Carum carvi, and Acorus calamus with enhanced antioxidant activity.Scientific reports · 2024Article
- Mechanisms and Applications of Citral's Antimicrobial Properties in Food Preservation and Pharmaceuticals Formulations.Antibiotics (Basel, Switzerland) · 2023Review
- Amphiphilic Polypeptides Obtained by Post-Polymerization Modification of Poly-l-Lysine as Systems for Combined Delivery of Paclitaxel and siRNA.Pharmaceutics · 2023Article
- Antioxidant-Mediated Modification of Citral and Its Control Effect on Mildewy Bamboo.Polymers · 2022Article
- Combination effect of epsilon-poly-L-lysine and antibiotics against common bacterial pathogens.The Journal of antibiotics · 2022Article
- The immunogenic reaction and bone defect repair function of ε-poly-L-lysine (EPL)-coated nanoscale PCL/HA scaffold in rabbit calvarial bone defect.Journal of materials science. Materials in medicine · 2021Article
- Phytochemical Analysis and Study of Antioxidant, Anticandidal, and Antibacterial Activities ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Entrapment ofPharmaceuticals (Basel, Switzerland) · 2020Article
- Optimization of the Production ofBioMed research international · 2020Article
- Comparative Evaluation of Combinatory Interaction between Endocannabinoid System Compounds and Poly-L-lysine againstBioMed research international · 2020Article
- Impact of Citral and Phloretin, Alone and in Combination, on Major Virulence Traits ofMolecules (Basel, Switzerland) · 2019Article
- Bacteria in Cancer Therapeutics: A Framework for Effective Therapeutic Bacterial Screening and Identification.Journal of Cancer · 2019Review
- Protective Effect ofFrontiers in pharmacology · 2019Article
- The Protective Effect ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Effect of citral on mouse hepatic cytochrome P450 enzymes.Pharmaceutical biology · 2018Article
- Chemical Composition and Evaluation of the Biological Properties of the Essential Oil of the Dietary Phytochemical Lippia citriodora.Molecules (Basel, Switzerland) · 2018Article
- Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Inflammasomes and Natural Ingredients towards New Anti-Inflammatory Agents.Molecules (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFood safety is an important worldwide public health concern, and microbial contamination in foods not only leads to food deterioration and shelf life reduction but also results in economic losses and disease.
objectiveThe main aim of the present study was to evaluate the effect of epsilon-poly-L-lysine (ε-PL) and citral combination against Escherichia coli O157:H7 (E. coli O157:H7) strains. The preliminary antioxidant and antitumor activities were also studied.
designSynergism is a positive interaction created when two compounds combine and exert an inhibitory effect that is greater than the sum of their individual effects. The synergistic antimicrobial effect of ε-PL and citral was studied using the checkerboard method against E. coli O157:H7. The minimal inhibitory concentration, time-kill, and scanning electron microscope assays were used to determine the antimicrobial activity of ε-PL and citral alone or in combination; 2,2-diphenyl-1-picrylhydrazyl-scavenging assay and western blotting were used in antioxidant activity assays; cell viability assay was carried out to finish preliminary antitumor test.
resultsMinimal inhibitory concentrations of ε-PL and citral resisted to the five E. coli O157:H7 strains were 2-4 µg/mL and 0.5-1 µg/mL, and the fractional inhibitory concentration indices were 0.25-0.375. The results of time-kill assay revealed that a stronger bactericidal effect in a laboratory medium might be exerted in the combination against E. coli O157:H7 than that in a food model. The compounds alone or in combination exhibited a potential 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity, and the expression of superoxide dismutase 1 and glutathione peroxidase 1 protein increased. The preliminary antitumor activity effect of the combination was better than ε-PL or citral alone.
conclusionsThese findings indicated that the combination of ε-PL and citral could not only be used as a promising naturally sourced food preservative but also be used in the pharmaceutical industry.
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