ArticleScientific reports2016
Organic bioelectronics probing conformational changes in surface confined proteins.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Label-free electronic detection of peptide post-translational modification with functional enzyme-driven assay at the physical limit.Cell reports. Physical science · 2024Article
- Experimental design of stencil-printed high-performance organic electrochemical transistors.Materials advances · 2023Article
- Molecular electronics behaviour of L-aspartic acid using symmetrical metal electrodes.Journal of molecular modeling · 2021Article
- Electrolyte-gated transistors for enhanced performance bioelectronics.Nature reviews. Methods primers · 2021Article
- First principle approach to elucidate transport properties through L-glutamic acid-based molecular devices using symmetrical electrodes.Journal of molecular modeling · 2020Article
- Development of Bioelectronic Devices Using Bionanohybrid Materials for Biocomputation System.Micromachines · 2019Review
- A Study on the Stability of Water-Gated Organic Field-Effect-Transistors Based on a Commercial p-Type Polymer.Frontiers in chemistry · 2019Article
- Single-molecule detection with a millimetre-sized transistor.Nature communications · 2018Article
- Article
- A thirst for advancement.Nature materials · 2018Article
- Extended Solution Gate OFET-based Biosensor for Label-free Glial Fibrillary Acidic Protein Detection with Polyethylene Glycol-Containing Bioreceptor Layer.Advanced functional materials · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of proteins confined on a surface has attracted a great deal of attention due to its relevance in the development of bio-systems for laboratory and clinical settings. In this respect, organic bio-electronic platforms can be used as tools to achieve a deeper understanding of the processes involving protein interfaces. In this work, biotin-binding proteins have been integrated in two different organic thin-film transistor (TFT) configurations to separately address the changes occurring in the protein-ligand complex morphology and dipole moment. This has been achieved by decoupling the output current change upon binding, taken as the transducing signal, into its component figures of merit. In particular, the threshold voltage is related to the protein dipole moment, while the field-effect mobility is associated with conformational changes occurring in the proteins of the layer when ligand binding occurs. Molecular Dynamics simulations on the whole avidin tetramer in presence and absence of ligands were carried out, to evaluate how the tight interactions with the ligand affect the protein dipole moment and the conformation of the loops surrounding the binding pocket. These simulations allow assembling a rather complete picture of the studied interaction processes and support the interpretation of the experimental results.
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