Evidence map›Paper›PMID 27312497›Full record

ArticleMethods in cell biology2016

Strategies for analyzing cardiac phenotypes in the zebrafish embryo.

A R Houk, D Yelon

Abstract read
In one paragraph

Article in Methods in cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. A zebrafish model of nicotinamide adenine dinucleotide (NADbioRxiv : the preprint server for biology · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2019
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

A R HoukUniversity of California, San Diego, CA, United States.
D YelonUniversity of California, San Diego, CA, United States.

Funding

Genetic Regulation of Cardiac Patterning in ZebrafishR01HL069594 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YELON, DEBORAH · 2002 to 2015
$4.0M
Genetic Regulation of Outflow Tract Formation in ZebrafishR01HL108599 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YELON, DEBORAH · 2011 to 2019
$3.4M
NHLBI NIH HHS R01 HL069594NHLBI NIH HHS R01 HL108599
6 · The paper itself

Abstract

The molecular mechanisms underlying cardiogenesis are of critical biomedical importance due to the high prevalence of cardiac birth defects. Over the past two decades, the zebrafish has served as a powerful model organism for investigating heart development, facilitated by its powerful combination of optical access to the embryonic heart and plentiful opportunities for genetic analysis. Work in zebrafish has identified numerous factors that are required for various aspects of heart formation, including the specification and differentiation of cardiac progenitor cells, the morphogenesis of the heart tube, cardiac chambers, and atrioventricular canal, and the establishment of proper cardiac function. However, our current roster of regulators of cardiogenesis is by no means complete. It is therefore valuable for ongoing studies to continue pursuit of additional genes and pathways that control the size, shape, and function of the zebrafish heart. An extensive arsenal of techniques is available to distinguish whether particular mutations, morpholinos, or small molecules disrupt specific processes during heart development. In this chapter, we provide a guide to the experimental strategies that are especially effective for the characterization of cardiac phenotypes in the zebrafish embryo.

Indexed as

AnimalsEmbryonic DevelopmentGene Expression Regulation, DevelopmentalHeartMorphogenesisMorpholinosMutationPhenotypeZebrafishMorpholinosAtrioventricular canalBlood flowCardiac chamber formationCardiac conductionCardiac contractilityCardiac morphogenesisCardiac specificationHeart developmentMyocardial differentiationTrabeculation

Identifiers

PMID27312497
PMCPMC5319864

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.