Evidence map›Paper›PMID 27312326›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2016

Long-term outcome of patients with virus-negative chronic myocarditis or inflammatory cardiomyopathy after immunosuppressive therapy.

Felicitas Escher, Uwe Kühl, Dirk Lassner, Wolfgang Poller, Dirk Westermann, Burkert Pieske, Carsten Tschöpe, Heinz-Peter Schultheiss

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Trial
  6. Article
  7. Review
  8. Cardiotoxicity induced by traditional chemotherapy: mechanisms and mitigation strategies.Apoptosis : an international journal on programmed cell death · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. The inflammatory spectrum of cardiomyopathies.Frontiers in cardiovascular medicine · 2024
    Review
  19. Review
  20. Klinische Padiatrie · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Felicitas EscherInstitute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany. felicitas.escher@charite.de.
Uwe KühlInstitute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany.
Dirk LassnerInstitute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany.
Wolfgang PollerDepartment of Cardiology, CBF, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Dirk WestermannUniversity Heart Center Hamburg, Hamburg, Germany.
Burkert PieskeDepartment of Cardiology, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Carsten TschöpeDepartment of Cardiology, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Heinz-Peter SchultheissInstitute for Cardiac Diagnostics and Therapy (IKDT), Berlin, Germany.
CS Diagnostics · DEGerman Centre for Cardiovascular Research · DECharité - Universitätsmedizin Berlin · DEUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo analyze the long-term outcome after immunosuppressive treatment of patients with virus-negative chronic myocarditis or inflammatory cardiomyopathy (CMi). METHODS AND

resultsWe investigated 114 patients with endomyocardial biopsy (EMB)-proven virus-negative chronic myocarditis or CMi, who were treated with prednisone and azathioprine for 6 months. Myocardial inflammation was assessed by quantitative immunohistology. We examined hemodynamic measurements after 6 months and long-term follow-up periods of up to 10 years {median 10.5 months [95 % confidence interval (CI) 11.69-59.16]}. At follow-up, the patients showed a significant improvement of left ventricular ejection fraction (LVEF) compared to baseline after 6-month period (LVEF rising from 44.6 ± 17.3 to 51.8 ± 15.5 %, p = 0.006) and in the long-term follow-up (LVEF 52.1 ± 15.6 %, p = 0.006). Simultaneously, EMB-analysis revealed significant reduction of quantified inflammatory infiltrates (CD3

conclusionsIn patients with virus-negative chronic myocarditis or CMi, we could show the effectiveness and beneficial effects of immunosuppressive treatment. Based on the normalization of the inflammatory process LVEF improvement is lasting for a long-term period of time.

Indexed as

Anti-Inflammatory AgentsAzathioprineBiopsyCardiomyopathiesFemaleGlucocorticoidsHumansImmunosuppressive AgentsMaleMyocarditisPrednisoneRecovery of FunctionRetrospective StudiesStroke VolumeTime FactorsTreatment OutcomeAnti-Inflammatory AgentsAzathioprineGlucocorticoidsImmunosuppressive AgentsPrednisoneEndomyocardial biopsyImmunosuppressive therapyInflammatory cardiomyopathyIntramyocardial inflammationLong-term follow-up

Identifiers

PMID27312326
OpenAlexW2420424132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.