ArticleArteriosclerosis, thrombosis, and vascular biology2016
Residential Proximity to Major Roads, Exposure to Fine Particulate Matter, and Coronary Artery Calcium: The Framingham Heart Study.
Abstract read
In one paragraph
Article in Arteriosclerosis, thrombosis, and vascular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Association between residential proximity to major roadways and low muscle mass among Chinese older adults: a nationwide cross-sectional study.BMC public health · 2025Article
- Integrating 4-D light-sheet fluorescence microscopy and genetic zebrafish system to investigate ambient pollutants-mediated toxicity.The Science of the total environment · 2023Review
- Impacts of Environmental Insults on Cardiovascular Aging.Current environmental health reports · 2022Review
- Links between chronic exposure to outdoor air pollution and cardiovascular diseases: a review.Environmental chemistry letters · 2022Review
- Air Pollution and Progression of Atherosclerosis in Different Vessel Beds-Results from a Prospective Cohort Study in the Ruhr Area, Germany.Environmental health perspectives · 2020Article
- Investigation of air pollution and noise on progression of thoracic aortic calcification: results of the Heinz Nixdorf Recall Study.European journal of preventive cardiology · 2020Article
- Residential Proximity to Major Roadways and Prevalent Hypertension Among Older Women and Men: Results From the Chinese Longitudinal Healthy Longevity Survey.Frontiers in cardiovascular medicine · 2020Article
- Article
- Radiographic pulmonary vessel volume, lung function and airways disease in the Framingham Heart Study.The European respiratory journal · 2019Article
- Association of Estimated Long-term Exposure to Air Pollution and Traffic Proximity With a Marker for Coronary Atherosclerosis in a Nationwide Study in China.JAMA network open · 2019Observational
- Cigarette Smoke Exposure and Radiographic Pulmonary Vascular Morphology in the Framingham Heart Study.Annals of the American Thoracic Society · 2019Article
- Aviation Noise and Cardiovascular Health in the United States: a Review of the Evidence and Recommendations for Research Direction.Current epidemiology reports · 2018Article
- Exposure to Traffic Emissions and Fine Particulate Matter and Computed Tomography Measures of the Lung and Airways.Epidemiology (Cambridge, Mass.) · 2018Article
- Ambient air pollution, adipokines, and glucose homeostasis: The Framingham Heart Study.Environment international · 2018Article
- Air Pollution and Cardiometabolic Disease: An Update and Call for Clinical Trials.American journal of hypertension · 2017Review
- Article
- Addressing Knowledge Gaps in the 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk: a Review of Recent Coronary Artery Calcium Literature.Current atherosclerosis reports · 2017Review
- Chromatin-modifying agents convert fibroblasts to OCT4+ and VEGFR-2+ capillary tube-forming cells.PloS one · 2017Article
- Residential Proximity to Major Roadways and Risk of Type 2 Diabetes Mellitus: A Meta-Analysis.International journal of environmental research and public health · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Kirsten S DoransFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Elissa H WilkerFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Wenyuan LiFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Mary B RiceFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Petter L LjungmanFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Joel SchwartzFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Brent A CoullFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Itai KloogFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Petros KoutrakisFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Ralph B D'AgostinoFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Joseph M MassaroFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Udo HoffmannFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Christopher J O'DonnellFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.).
Murray A MittlemanFrom the Department of Epidemiology (K.S.D., E.H.W., W.L., J.S., M.A.M.), Department of Environmental Health (E.H.W., J.S., P.K.), and Department of Biostatistics (B.A.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Cardiovascular Epidemiology Research Unit, Department of Cardiology, Beth Israel Deaconess Medical Center (K.S.D., E.H.W., W.L., M.B.R., P.L.L., M.A.M.), Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center (M.B.R.), Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital (U.H.), and Cardiovascular Medicine, Brigham and Women's Hospital (C.J.O.), Harvard Medical School, Boston, MA; Unit of Environmental Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (P.L.L.); Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel (I.K.); National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.B.D., J.M.M., C.J.O.); Department of Mathematics and Statistics, Boston University, MA (R.B.D.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (J.M.M.); and Cardiology Section, Department of Medicine, Boston Veteran's Administration Health System, Boston, MA (C.J.O.). mmittlem@hsph.harvard.edu.
Funding
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Brent Andrew Coull · 1985 to 2026
$44.6MTraining Program in the Epidemiology of CVDT32HL007575 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BURING, JULIE E., RIDKER, PAUL M. · 1985 to 2019
$5.0MAir Pollution and the Lung in Health and COPD: Obstructive, Restrictive and Vascular PathwaysK23ES026204 · NIEHS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RICE, MARY B · 2016 to 2020
$883kTraffic pollution, brain structure and cognitive functionR00ES022243 · NIEHS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WILKER, ELISSA · 2016 to 2018
$747kTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–NHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NHLBI NIH HHS T32 HL007575NIEHS NIH HHS K23 ES026204NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R00 ES022243
Abstract
objectiveLong-term exposure to traffic and particulate matter air pollution is associated with a higher risk of cardiovascular disease, potentially via atherosclerosis promotion. Prior research on associations of traffic and particulate matter with coronary artery calcium Agatston score (CAC), an atherosclerosis correlate, has yielded inconsistent findings. Given this background, we assessed whether residential proximity to major roadway or fine particulate matter were associated with CAC in a Northeastern US study. APPROACH AND
resultsWe measured CAC ≤2 times from 2002 to 2005 and 2008 to 2011 among Framingham Offspring or Third-Generation Cohort participants. We assessed associations of residential distance to major roadway and residential fine particulate matter (2003 average; spatiotemporal model) with detectable CAC, using generalized estimating equation regression. We used linear mixed effects models to assess associations with loge(CAC). We also assessed associations with CAC progression. Models were adjusted for demographic variables, socioeconomic position markers, and time. Among 3399 participants, 51% had CAC measured twice. CAC was detectable in 47% of observations. At first scan, mean age was 52.2 years (standard deviation 11.7); 51% male. There were no consistent associations with detectable CAC, continuous CAC, or CAC progression. We observed heterogeneous associations of distance to major roadway with odds of detectable CAC by hypertensive status; interpretation of these findings is questionable.
conclusionsOur findings add to prior work and support evidence against strong associations of traffic or fine particulate matter with the presence, extent, or progression of CAC in a region with relatively low levels of and little variation in fine particulate matter.
Indexed as
AutomobilesHousingVehicle EmissionsAgedAir PollutantsCoronary AngiographyCoronary Artery DiseaseEnvironmental ExposureEnvironmental MonitoringFemaleHumansLinear ModelsLogistic ModelsMaleMassachusettsMiddle AgedAir PollutantsParticulate MatterVehicle Emissionsair pollutionatherosclerosiscoronary artery calciumepidemiologymultidetector computed tomography
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.