ReviewBJOG : an international journal of obstetrics and gynaecology2017
A review of the available clinical therapies for vulvodynia management and new data implicating proinflammatory mediators in pain elicitation.
Review in BJOG : an international journal of obstetrics and gynaecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03390049 (Randomized Controlled Trial of Fractional CO2 Laser vs Sham Laser for Women With Provoked Vestibulodynia Who Have Failed Conservative Management), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial of Fractional CO2 Laser vs Sham Laser for Women With Provoked Vestibulodynia Who Have Failed Conservative Management
Who cites it
26 citing papers in PubMed.
- Testing peripheral and central therapies for provoked vestibulodynia: results from the UPDATe trial.Annals of medicine · 2026Trial
- Molecular mechanisms and therapeutic perspectives in vulvodynia: From current evidence to future investigations.Cell reports. Medicine · 2026Review
- Soluble epoxide hydrolase inhibition restores pro-resolving lipid mediators and reduces inflammation in localized provoked vulvodynia.Frontiers in pharmacology · 2026Article
- Impact of Vulvodynia on the Quality of Life of Women: A Rapid Review.Journal of clinical medicine · 2025Review
- A cautionary tale: Non-steroidal anti-inflammatory drug use and localized provoked vulvodynia.The journal of pain · 2025Article
- Article
- Dysregulation of Arachidonic Acid Metabolism Drives Inflammatory Lipid Production in Localized Provoked Vulvodynia.Nutrients · 2025Article
- Clinical Evidence Regarding Spermidine-Hyaluronate Gel as a Novel Therapeutic Strategy in Vestibulodynia Management.Pharmaceutics · 2024Article
- Vulvodynia - A contemporary understanding and practical approach in primary care settings.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2024Review
- Inflammation, lipids, and pain in vulvar disease.Pharmacology & therapeutics · 2023Review
- Comparison of pain catastrophizing and anxiety in patients with dyspareunia and healthy women: a cross-sectional study.Journal of medicine and life · 2023Article
- Vulvodynia: Pain Management Strategies.Pharmaceuticals (Basel, Switzerland) · 2022Review
- High-Intensity Laser Therapy (HILT) as an Emerging Treatment for Vulvodynia and Chronic Musculoskeletal Pain Disorders: A Systematic Review of Treatment Efficacy.Journal of clinical medicine · 2022Review
- Specialized Pro-resolving Mediators Reduce Pro-nociceptive Inflammatory Mediator Production in Models of Localized Provoked Vulvodynia.The journal of pain · 2021Article
- Clodronate Treatment Prevents Vaginal Hypersensitivity in a Mouse Model of Vestibulodynia.Frontiers in cellular and infection microbiology · 2021Article
- Cannabis and Vulvodynia Symptoms: A Preliminary Report.Cannabis (Albuquerque, N.M.) · 2020Article
- Vulvodynia.Nature reviews. Disease primers · 2020Review
- Expression of Estrogen-Related Receptors in Localized Provoked Vulvodynia.BioResearch open access · 2020Article
- Algorithms for Managing Vulvovaginal Symptoms-a Practical Primer.Current infectious disease reports · 2019Review
- Vulvodynia: A Review of the Literature.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Localised provoked vulvodynia (LPV) is a common, chronic, and disabling condition: patients experience profound pain and a diminished quality of life. The aetiologic origins of vulvodynia are poorly understood, yet recent evidence suggests a link to site-specific inflammatory responses. Fibroblasts isolated from the vestibule of LPV patients are sensitive to proinflammatory stimuli and copiously produce pain-associated proinflammatory mediators (IL-6 and PGE TWEETABLE ABSTRACT: Vulvodynia is a poorly understood, prevalent, and serious women's health issue requiring better understanding to improve therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.