ArticleEMBO molecular medicine2016
Defining the optimal animal model for translational research using gene set enrichment analysis.
Article in EMBO molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- A Cross-Species and Sex-Specific Meta-Analysis of Transcriptomic Studies of Pulmonary Hypertension.American journal of respiratory cell and molecular biology · 2025Pooled it
- Protection of macrophages from intracellular pathogens by miR-182-5p mimic-a gene expression meta-analysis approach.The FEBS journal · 2018Pooled it
- Leveraging Dog Models to Uncover Human Cancer Insights.Research square · 2026Article
- Bioprinted Four-Cell-Type Lung Model for Viral Infection Studies Under Air-Liquid Interface Conditions.International journal of molecular sciences · 2025Article
- Transcriptomic congruence analysis for evaluating model organisms.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Vascular Proteome Responses Precede Organ Dysfunction in a Murine Model of Staphylococcus aureus Bacteremia.mSystems · 2022Article
- Human pathways in animal models: possibilities and limitations.Nucleic acids research · 2021Article
- Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma.Journal of hematology & oncology · 2020Article
- Effects of first-generation in utero exposure to diesel engine exhaust on second-generation placental function, fatty acid profiles and foetal metabolism in rabbits: preliminary results.Scientific reports · 2019Article
- Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling.Journal of experimental & clinical cancer research : CR · 2019Article
- Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma.American journal of cancer research · 2019Article
- Journey into Bone Models: A Review.Genes · 2018Review
- A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research.Journal of visualized experiments : JoVE · 2017Article
- Porcine familial adenomatous polyposis model enables systematic analysis of early events in adenoma progression.Scientific reports · 2017Article
- KERIS: kaleidoscope of gene responses to inflammation between species.Nucleic acids research · 2017Article
- Translational Rodent Models for Research on Parasitic Protozoa-A Review of Confounders and Possibilities.Frontiers in cellular and infection microbiology · 2017Review
- Defining the optimal animal model for translational research using gene set enrichment analysis.EMBO molecular medicine · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse is the main model organism used to study the functions of human genes because most biological processes in the mouse are highly conserved in humans. Recent reports that compared identical transcriptomic datasets of human inflammatory diseases with datasets from mouse models using traditional gene-to-gene comparison techniques resulted in contradictory conclusions regarding the relevance of animal models for translational research. To reduce susceptibility to biased interpretation, all genes of interest for the biological question under investigation should be considered. Thus, standardized approaches for systematic data analysis are needed. We analyzed the same datasets using gene set enrichment analysis focusing on pathways assigned to inflammatory processes in either humans or mice. The analyses revealed a moderate overlap between all human and mouse datasets, with average positive and negative predictive values of 48 and 57% significant correlations. Subgroups of the septic mouse models (i.e., Staphylococcus aureus injection) correlated very well with most human studies. These findings support the applicability of targeted strategies to identify the optimal animal model and protocol to improve the success of translational research.
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