ArticleScientific reports2016
FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Physio-metabolic and clinical consequences of wearing face masks-Systematic review with meta-analysis and comprehensive evaluation.Frontiers in public health · 2023Pooled it
- Systematic comparison of methods for offline breath sampling.Analytical and bioanalytical chemistry · 2025Article
- Estimating hypoxia-induced brain dysfunction and cognitive decline through exhaled breath monitoring.Respiratory research · 2025Article
- Effects of Contagious Respiratory Pathogens on Breath Biomarkers.Antioxidants (Basel, Switzerland) · 2024Article
- Origin of breath isoprene in humans is revealed via multi-omic investigations.Communications biology · 2023Article
- Advanced setup for safe breath sampling and patient monitoring under highly infectious conditions in the clinical environment.Scientific reports · 2022Article
- Effects of COVID-19 protective face masks and wearing durations on respiratory haemodynamic physiology and exhaled breath constituents.The European respiratory journal · 2022Article
- Real-time metabolic monitoring under exhaustive exercise and evaluation of ventilatory threshold by breathomics: Independent validation of evidence and advances.Frontiers in physiology · 2022Article
- A comparison of alternative selection methods for reporting spirometric parameters in healthy adults.Scientific reports · 2021Article
- Total OH Reactivity of Emissions from Humans: In Situ Measurement and Budget Analysis.Environmental science & technology · 2021Article
- Deficiency and absence of endogenous isoprene in adults, disqualified its putative origin.Heliyon · 2021Article
- Effects of modular ion-funnel technology onto analysis of breath VOCs by means of real-time mass spectrometry.Analytical and bioanalytical chemistry · 2020Article
- Exhaled breath compositions under varying respiratory rhythms reflects ventilatory variations: translating breathomics towards respiratory medicine.Scientific reports · 2020Article
- Changes of Exhaled Volatile Organic Compounds in Postoperative Patients Undergoing Analgesic Treatment: A Prospective Observational Study.Metabolites · 2020Article
- Unravelling the Potential of Salivary Volatile Metabolites in Oral Diseases. A Review.Molecules (Basel, Switzerland) · 2020Review
- Exhaled volatile substances in children suffering from type 1 diabetes mellitus: results from a cross-sectional study.Scientific reports · 2019Article
- Non-Invasive Assessment of Metabolic Adaptation in Paediatric Patients Suffering from Type 1 Diabetes Mellitus.Journal of clinical medicine · 2019Article
- Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry.Analytical and bioanalytical chemistry · 2019Article
- Volatilomic insight of head and neck cancer via the effects observed on saliva metabolites.Scientific reports · 2018Article
- Natural menstrual rhythm and oral contraception diversely affect exhaled breath compositions.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breath volatile organic compound (VOC) analysis can open a non-invasive window onto pathological and metabolic processes in the body. Decades of clinical breath-gas analysis have revealed that changes in exhaled VOC concentrations are important rather than disease specific biomarkers. As physiological parameters, such as respiratory rate or cardiac output, have profound effects on exhaled VOCs, here we investigated VOC exhalation under respiratory manoeuvres. Breath VOCs were monitored by means of real-time mass-spectrometry during conventional FEV manoeuvres in 50 healthy humans. Simultaneously, we measured respiratory and hemodynamic parameters noninvasively. Tidal volume and minute ventilation increased by 292 and 171% during the manoeuvre. FEV manoeuvre induced substance specific changes in VOC concentrations. pET-CO2 and alveolar isoprene increased by 6 and 21% during maximum exhalation. Then they decreased by 18 and 37% at forced expiration mirroring cardiac output. Acetone concentrations rose by 4.5% despite increasing minute ventilation. Blood-borne furan and dimethyl-sulphide mimicked isoprene profile. Exogenous acetonitrile, sulphides, and most aliphatic and aromatic VOCs changed minimally. Reliable breath tests must avoid forced breathing. As isoprene exhalations mirrored FEV performances, endogenous VOCs might assure quality of lung function tests. Analysis of exhaled VOC concentrations can provide additional information on physiology of respiration and gas exchange.
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