ArticleMetabolic brain disease2016
Geniposide alleviates depression-like behavior via enhancing BDNF expression in hippocampus of streptozotocin-evoked mice.
Article in Metabolic brain disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Effectiveness and safety of commercial Chinese polyherbal preparations combined with menopausal hormone therapy for perimenopausal symptoms: a network meta-analysis of randomized controlled trials.Frontiers in pharmacology · 2026Pooled it
- Comparing the effect of fluoxetine, escitalopram, and sertraline, on the level of BDNF and depression in preclinical and clinical studies: a systematic review.European journal of clinical pharmacology · 2024Pooled it
- Voluntary wheel running in male mice mitigates select hyperglycemia-induced depressive-like behaviors and modulates BDNF andBrain, behavior, & immunity - health · 2026Article
- Therapeutic potential of plant iridoids in depression: a review.Pharmaceutical biology · 2022Review
- CaMKIV/CREB/BDNF signaling pathway expression in prefrontal cortex, amygdala, hippocampus and hypothalamus in streptozotocin-induced diabetic mice with anxious-like behavior.Experimental brain research · 2022Article
- Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide.Molecules (Basel, Switzerland) · 2022Review
- Kamikihito rescued depressive-like behaviors and hippocampus neurogenesis in chronic restraint stress rats.Journal of traditional and complementary medicine · 2022Article
- The Rapid and Long-Lasting Antidepressant Effects of Iridoid Fraction inFrontiers in pharmacology · 2022Article
- The Role of Natural Products in Treatment of Depressive Disorder.Current neuropharmacology · 2022Article
- The emerging possibility of the use of geniposide in the treatment of cerebral diseases: a review.Chinese medicine · 2021Review
- Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus.International journal of bipolar disorders · 2021Article
- The protective effect of Geniposide on diabetic cognitive impairment through BTK/TLR4/NF-κB pathway.Psychopharmacology · 2020Article
- Depression with Comorbid Diabetes: What Evidence Exists for Treatments Using Traditional Chinese Medicine and Natural Products?Frontiers in pharmacology · 2020Review
- Antidepressant-Like Effect ofFrontiers in molecular neuroscience · 2020Article
- Geniposide Alleviates Oxidative Stress of Mice With Depression-Like Behaviors by Upregulating Six3os1.Frontiers in cell and developmental biology · 2020Article
- Diverse Pharmacological Activities and Potential Medicinal Benefits of Geniposide.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- The Potential Antipyretic Mechanism of Gardeniae Fructus and Its Heat-Processed Products With Plasma Metabolomics Using Rats With Yeast-Induced Fever.Frontiers in pharmacology · 2019Article
- Antidepressant and anxiolytic like effects of Urtica dioica leaves in streptozotocin induced diabetic mice.Metabolic brain disease · 2018Article
- Zeaxanthin improved diabetes-induced anxiety and depression through inhibiting inflammation in hippocampus.Metabolic brain disease · 2018Article
- Identification of Steroidogenic Components Derived FromFrontiers in pharmacology · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical and preclinical data suggest that diabetes is often psychological complications such as depression. Geniposide (GP), a major compound in Gardenia jasminoides Ellis with both medicinal and nutritional values, has been previously confirmed to exert anti-diabetic and anti-depressive activities. The present study attempted to observe anti-depressive mechanisms of GP in streptozotocin (STZ) evoked diabetic mice by involving brain-derived neurotrophic factor (BDNF), for the first time. Mice were given GP daily (50, and 100 mg/kg, ig) or reference drugs FHMH [fluoxetine hydrochloride (FH, 10 mg/kg, ig) combined with metformin hydrochloride (MH, 100 mg/kg, ig)] for 3 weeks. The forced swimming test (FST) was performed to observe depression-like behavior, and serum and brain tissues were used for neurochemical and fluorescent quantitative reverse transcription PCR analyses. STZ induced excessively increased blood sugar and immobility time in FST, in a manner attenuated by GP and FHMH administration. GP administration further elevated BDNF levels, and up-regulated the mRNA expression of BDNF and tropomyosin-related kinase B (TrkB) in hippocampus of diabetic mice. In addition, STZ induced the excessive level of serum corticosterone (CORT), while GP did not influence on it in diabetic mice. Taken together, these findings indicate that GP can alleviate depression-like behavior in STZ-evoked diabetic mice, and suggest its mechanisms may partially be ascribed to up-regulating BDNF expression in brain.
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