Observational studyScientific reports2016
Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting.
Observational study in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Role of GDF-15 in diabetic nephropathy: mechanisms, diagnosis, and therapeutic potential.International urology and nephrology · 2025Review
- Growth Differentiation Factor 15 as a Biomarker for Risk Stratification in the Cardiothoracic Surgery Intensive Care Unit.Biomolecules · 2024Article
- Serum growth differentiation factor-15 and non-esterified fatty acid levels in patients with coronary artery disease and hyperuricemia.Lipids in health and disease · 2023Article
- GDF15, an update of the physiological and pathological roles it plays: a review.Pflugers Archiv : European journal of physiology · 2020Review
- The Role of Growth Differentiation Factor 15 in Energy Metabolism.Diabetes & metabolism journal · 2020Review
- Pericardial fluid levels of growth differentiation factor 15 in patients with or without coronary artery disease: a prospective study.Annals of translational medicine · 2020Article
- Serum GDF15, a Promising Biomarker in Obese Patients Undergoing Heart Surgery.Frontiers in cardiovascular medicine · 2020Article
- Growth Differentiation Factor-15 (GDF-15) is a Biomarker of Muscle Wasting and Renal Dysfunction in Preoperative Cardiovascular Surgery Patients.Journal of clinical medicine · 2019Article
- Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease.Cardiovascular diabetology · 2019Article
- Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis.Experimental and therapeutic medicine · 2018Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth differentiation factor-15 (GDF-15) has recently emerged as a risk predictor in patients with cardiovascular diseases. We therefore aimed to investigate the role of GDF-15 in the occurrence of cardiac injury during off-pump coronary artery bypass grafting (OPCAB). 55 consecutive patients with coronary artery diseases were recruited in this prospective, observational study. All patients were operated for OPCAB surgery. Serial blood samples were collected preoperatively, 12 hours and 36 hours after surgery. GDF-15, together with C-reactive protein, cardiac troponin I, creatine kinase MB and N-terminal pro B-type natriuretic peptide levels in plasma were measured at each time-point. GDF-15 levels increased significantly at 12 hours after surgery, attaining nearly 2.5 times the baseline levels (p < 0.001). Postoperative GDF-15 levels correlated positively with cTnI (p = 0.003) and EuroSCORE II (p = 0.013). According to the ROC curves, postoperative plasma GDF-15 was found to be the best biomarker to predict perioperative cardiac injury, compared with cTnI, CK-MB and EuroSCORE II. Circulating GDF-15 is a promising novel biomarker for identifying perioperative myocardial injury in patients undergoing OPCAB.
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