ArticlePloS one2016
CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Human labour is associated with altered regulatory T cell function and maternal immune activation.Clinical and experimental immunology · 2020Trial
- Spontaneous Pregravid Obesity Reshapes Fetal Immune Ontogeny in a Nonhuman Primate Model.bioRxiv : the preprint server for biology · 2026Article
- Effects of Notch signaling on the lineage commitment of human peripheral blood monocyte trilineage progenitor under inflammatory conditions.Cell death discovery · 2025Article
- Inhibition of CSF-1R and IL-6R prevents conversion of cDC2s into immune incompetent tumor-induced DC3s boosting DC-driven therapy potential.Cell reports. Medicine · 2024Article
- Prevalence of hybrid TLR4Frontiers in immunology · 2024Article
- Age-related changes of the innate immune system of the palatine tonsil in a healthy cohort.Frontiers in immunology · 2023Article
- Human macrophages and monocyte-derived dendritic cells stimulate the proliferation of endothelial cells through midkine production.PloS one · 2022Article
- Functionally Mature CD1cFrontiers in immunology · 2021Article
- Intratumoral Combinatorial Administration of CD1c (BDCA-1)Vaccines · 2020Article
- Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans.Immunity · 2020Article
- Myeloid Cells Enriched for a Dendritic Cell Population From People Living With HIV Have Altered Gene Expression Not Restored by Antiretroviral Therapy.Frontiers in immunology · 2020Article
- Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease.Frontiers in immunology · 2020Review
- Subsets of CD1cFrontiers in immunology · 2020Review
- Two distinct colonic CD14Mucosal immunology · 2019Article
- Circulating Plasmacytoid and Myeloid Dendritic Cells in Breast Cancer Patients: A Pilot Study.Journal of breast cancer · 2019Article
- The CD14Frontiers in immunology · 2019Review
- Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection.Frontiers in immunology · 2019Review
- Review
- Transcriptional profiling reveals monocyte-related macrophages phenotypically resembling DC in human intestine.Mucosal immunology · 2018Article
- Human dendritic cell subsets: an update.Immunology · 2018Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional dendritic cells (cDCs) comprise a heterogeneous population of cells that are important regulators of immunity and homeostasis. CD1c+ cDCs are present in human blood and tissues, and found to efficiently activate naïve CD4+ T cells. While CD1c is thought to specifically identify this subset of human cDCs, we show here that also classical and intermediate monocytes express CD1c. Accordingly, the commercial CD1c (BDCA-1)+ Dendritic Cell Isolation Kit isolates two distinct cell populations from blood: CD1c+CD14- cDCs and CD1c+CD14+ monocytes. CD1c+ cDCs and CD1c+ monocytes exhibited strikingly different properties, including their differential regulation of surface marker expression, their levels of cytokine production, and their ability to stimulate naïve CD4+ T cells. These results demonstrate that a commercial CD1c (BDCA-1)+ Dendritic Cell Isolation Kit isolates two functionally different cell populations, which has important implications for the interpretation of previously generated data using this kit to characterize CD1c+ cDCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.