ArticlePLoS genetics2016
Mating-Induced Increase in Germline Stem Cells via the Neuroendocrine System in Female Drosophila.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 97 citations in OpenAlex.
- Effects of collection and storage methods of Samia cynthia ricini egg on the reproduction of Trichogramma chilonis.Pest management science · 2026Article
- Ecdysone receptor autonomously controls germ cell differentiation in the Drosophila ovary.Development (Cambridge, England) · 2026Article
- Microbe-dependent inter-organ communication regulates germline stem cell proliferation inbioRxiv : the preprint server for biology · 2026Article
- Insect Lipidomics: Advances, Applications, and Physiological Insights.Advances in experimental medicine and biology · 2026Review
- Article
- Venerose: a nuptial gift with implications.Journal of neurogenetics · 2025Article
- Steroid hormone-induced wingless ligands tune female intestinal size in Drosophila.Nature communications · 2025Article
- Germline expression of Imp-L2 in Drosophila females enhances reproductive activity and longevity.Animal cells and systems · 2025Article
- Gut-to-brain regulation ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- A sexually transmitted sugar orchestrates reproductive responses to nutritional stress.Nature communications · 2024Article
- Gut-to-brain regulation ofbioRxiv : the preprint server for biology · 2024Article
- Conditional Inhibition of Eip75B Eliminates the Effects of Mating and Mifepristone on Lifespan in FemaleCells · 2024Article
- Mating-induced Ecdysone in the testis disrupts soma-germline contacts and stem cell cytokinesis.Development (Cambridge, England) · 2024Article
- Mating-induced increase of kynurenine in Drosophila ovary enhances starvation resistance of progeny.The Journal of biological chemistry · 2024Article
- Finishing the egg.Genetics · 2024Article
- Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways.Communications biology · 2023Article
- Mating-induced ecdysone in the testis disrupts soma-germline contacts and stem cell cytokinesis.bioRxiv : the preprint server for biology · 2023Article
- Single-cell RNA sequencing identifies eggplant as a regulator of germ cell development in Drosophila.EMBO reports · 2023Article
- Ecdysteroid Biosynthesis Halloween GeneInternational journal of molecular sciences · 2023Article
- Circulating fructose regulates a germline stem cell increase via gustatory receptor-mediated gut hormone secretion in matedScience advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mating and gametogenesis are two essential components of animal reproduction. Gametogenesis must be modulated by the need for gametes, yet little is known of how mating, a process that utilizes gametes, may modulate the process of gametogenesis. Here, we report that mating stimulates female germline stem cell (GSC) proliferation in Drosophila melanogaster. Mating-induced increase in GSC number is not simply owing to the indirect effect of emission of stored eggs, but rather is stimulated by a male-derived Sex Peptide (SP) and its receptor SPR, the components of a canonical neuronal pathway that induces a post-mating behavioral switch in females. We show that ecdysteroid, the major insect steroid hormone, regulates mating-induced GSC proliferation independently of insulin signaling. Ovarian ecdysteroid level increases after mating and transmits its signal directly through the ecdysone receptor expressed in the ovarian niche to increase the number of GSCs. Impairment of ovarian ecdysteroid biosynthesis disrupts mating-induced increase in GSCs as well as egg production. Importantly, feeding of ecdysteroid rescues the decrease in GSC number caused by impairment of neuronal SP signaling. Our study illustrates how female GSC activity is coordinately regulated by the neuroendocrine system to sustain reproductive success in response to mating.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.