ArticleeLife2016
Sensory experience modifies feature map relationships in visual cortex.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Binocular Circuitry as a Model for Understanding Experience-Dependent Circuit Development across the Mammalian Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- The world through infant eyes: Evidence for the early emergence of the cardinal orientation bias.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Orientation pinwheels in primary visual cortex of a highly visual marsupial.Science advances · 2022Article
- The Role of Visual Experience in Individual Differences of Brain Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces.Nature communications · 2022Article
- The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity.Frontiers in neuroanatomy · 2022Article
- Development and Reorganization of Orientation Representation in the Cat Visual Cortex: Experience-Dependent Synaptic Rewiring in Early Life.Frontiers in neuroinformatics · 2020Article
- Origins of Functional Organization in the Visual Cortex.Frontiers in systems neuroscience · 2020Review
- Comparison of contrast-dependent phase sensitivity in primary visual cortex of mouse, cat and macaque.Neuroreport · 2019Article
- Theoretical Models of Neural Development.iScience · 2018Review
- The Active Side of Stereopsis: Fixation Strategy and Adaptation to Natural Environments.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extent to which brain structure is influenced by sensory input during development is a critical but controversial question. A paradigmatic system for studying this is the mammalian visual cortex. Maps of orientation preference (OP) and ocular dominance (OD) in the primary visual cortex of ferrets, cats and monkeys can be individually changed by altered visual input. However, the spatial relationship between OP and OD maps has appeared immutable. Using a computational model we predicted that biasing the visual input to orthogonal orientation in the two eyes should cause a shift of OP pinwheels towards the border of OD columns. We then confirmed this prediction by rearing cats wearing orthogonally oriented cylindrical lenses over each eye. Thus, the spatial relationship between OP and OD maps can be modified by visual experience, revealing a previously unknown degree of brain plasticity in response to sensory input.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.