ArticleAutophagy2016
Autophagy regulates spermatid differentiation via degradation of PDLIM1.
Article in Autophagy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
78 citing papers in PubMed, 149 citations in OpenAlex.
- Beclin1 Regulates Sertoli Cell Function to Maintain Mouse Spermatogenesis.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Adipose-Derived Mesenchymal Stem Cells and Their Exosomes Ameliorate Sperm-related Abnormalities, Hormonal Imbalance, and Disrupted Testicular Autophagy in A Diet-Induced Murine Model for Non-Alcoholic Fatty Liver Disease.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Zingerone supplementation stimulates germ cell proliferation, inhibits apoptosis and modulates autophagy and ferroptosis in the mice testis.Journal of molecular histology · 2026Article
- Targeting programmed cell death in male infertility: pathogenic mechanisms and therapeutic strategies.Molecular biology reports · 2026Review
- Regulation of mitochondrial function during spermatogenesis and sperm maturation.Cellular & molecular biology letters · 2026Review
- Oxidative Stress-Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis.Journal of cellular and molecular medicine · 2026Review
- Mytho/Phaf1 is required to prevent DNA damage and tissue degeneration in Danio rerio.Cell death discovery · 2026Article
- Effect of autophagy-related (Atg) protein 5 on mouse epididymal sperm maturation.Journal of assisted reproduction and genetics · 2026Article
- Nor1 and Mitophagy: An Insight into Sertoli Cell Function Regulating Spermatogenesis Using a Transgenic Rat Model.International journal of molecular sciences · 2025Article
- Biological Modulation of Autophagy by Nanoplastics: A Current Overview.International journal of molecular sciences · 2025Review
- Visualizing bulk autophagyAutophagy · 2025Article
- Innate Antiviral Defense of the Male Reproductive System.Advances in experimental medicine and biology · 2025Review
- Stage-specific autophagy dynamics in reproductive processes and associated disorders.Frontiers in cell and developmental biology · 2025Review
- Ultrastructural evidence for the activation of autophagy and analysis of the protective role of autophagy in goat spermatozoa under liquid storage.Frontiers in veterinary science · 2025Article
- Neurodegenerative diseases and neuroinflammation-induced apoptosis.Open life sciences · 2025Review
- Activation of autophagy is required for clearance of mitochondrial ROS in patients with asthenozoospermia.PeerJ · 2025Article
- Autophagy in reproduction and pregnancy-associated diseases.iScience · 2024Review
- Autophagy modulates Arabidopsis male gametophyte fertility and controls actin organization.Nature communications · 2024Article
- Autophagy accompanying the developmental process of male germline stem cells.Cell and tissue research · 2024Review
- Bioinformatics Identification and Experimental Verification of Disulfidptosis-Related Genes in the Progression of Osteoarthritis.Biomedicines · 2024Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spermiogenesis is a complex and highly ordered spermatid differentiation process that requires reorganization of cellular structures. We have previously found that Atg7 is required for acrosome biogenesis. Here, we show that autophagy regulates the round and elongating spermatids. Specifically, we found that Atg7 is required for spermatozoa flagella biogenesis and cytoplasm removal during spermiogenesis. Spermatozoa motility of atg7-null mice dropped significantly with some extra-cytoplasm retained on the mature sperm head. These defects are associated with an impairment of the cytoskeleton organization. Functional screening revealed that the negative cytoskeleton organization regulator, PDLIM1 (PDZ and LIM domain 1 [elfin]), needs to be degraded by the autophagy-lysosome-dependent pathway to facilitate the proper organization of the cytoskeleton. Our results thus provide a novel mechanism showing that autophagy regulates cytoskeleton organization mainly via degradation of PDLIM1 to facilitate the differentiation of spermatids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.