Evidence map›Paper›PMID 27310259›Full record

SynthesisPloS one2016

Rheumatoid Arthritis Disadvantages Younger Patients for Cardiovascular Diseases: A Meta-Analysis.

Jaap Fransen, Seyyed M R Kazemi-Bajestani, Sebastian J H Bredie, Calin D Popa

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03821090 (A Study in Subclinical Atherosclerosis in Patients With Rheumatoid Arthritis), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03821090 completednot on this mapstarted 2019, after this paper: background citation

A Study in Subclinical Atherosclerosis in Patients With Rheumatoid Arthritis

TypeobservationalSponsorAssiut UniversityRan2019 to 2021Enrolled160ConditionsRheumatoid Arthritis
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Sex and Management of Rheumatoid Arthritis.Clinical reviews in allergy & immunology · 2019
    Review
  15. Article
  16. Article
  17. Review
  18. Observational
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Jaap FransenDepartment of Rheumatology Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Seyyed M R Kazemi-BajestaniDepartment of Oncology, Faculty of Medicine, University of Alberta, Edmonton, Canada.
Sebastian J H BredieDepartment of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Calin D PopaDepartment of Rheumatology Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Radboud University Medical Center · NLRadboud University Nijmegen · NLUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe incidence of cardiovascular diseases (CVD) is increased in rheumatoid arthritis (RA) patients. It remains unclear whether the load of RA increases cardiovascular (CV) risk especially in female and in younger RA patients. In the present study we aim to analyse the influence of age and gender on CV risk in RA relative to the general population, using meta-analysis of direct comparative studies.

methodSystematic literature search was performed in MEDLINE for studies reporting on occurrence of CV events in RA as compared to the general population, stratified for gender and/or age. Quality was appraised using the Newcastle-Ottawa scale. Meta-analysis was performed on rate ratios using inverse variance methods.

resultsThere were 1372 records screened and 13 studies included. RA females and males have a similar higher risk (95%CI) to develop stroke with RR 1.35 (1.30-1.40) and RR 1.31 (1.21-1.43); coronary artery disease with RR 1.65 (1.54-1.76) versus RR 1.55 ((1.41-1.69) in men; cardiovascular disease with RR 1.56 (1.49-1.62) versus 1.50 (1.41-1.60). The highest incidence of CV events was observed in the youngest patients, RR 2.59 (1.77-3.79), whereas older patients had the lowest relative risk when compared to the general population, RR 1.27 (1.16-1.38).

conclusionThe relative risk of RA patients for CVD is age dependent, but does not depend on gender: the relative risk on CVD appears to be equally raised for males and females, while relatively young RA patients (<50 years) have the highest, and older patients the lowest relative risk.

Indexed as

AdolescentAdultAgedAged, 80 and overAge FactorsArthritis, RheumatoidCoronary Artery DiseaseFemaleHumansIncidenceMaleMiddle AgedNetherlandsRisk FactorsStroke

Identifiers

PMID27310259
PMCPMC4911000
OpenAlexW2441060902

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.