ReviewCanadian journal of psychiatry. Revue canadienne de psychiatrie2017
Do the Trajectories of Bipolar Disorder and Schizophrenia Follow a Universal Staging Model?
Review in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Longitudinal studies of bipolar patients and their families: translating findings to advance individualized risk prediction, treatment and research.International journal of bipolar disorders · 2024Review
- Developing a clinical decision tool based on electroretinogram to monitor the risk of severe mental illness.BMC psychiatry · 2022Article
- Consensus on nomenclature for clinical staging models in bipolar disorder: A narrative review from the International Society for Bipolar Disorders (ISBD) Staging Task Force.Bipolar disorders · 2021Review
- Preventive psychiatry: a blueprint for improving the mental health of young people.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Effects of Lithium Combined with Second-Generation Antipsychotics for the Treatment of Manic Episodes in Patients with Bipolar Disorder: A Naturalistic Study in China.Neuropsychiatric disease and treatment · 2020Article
- Shedding light on the onset of psychiatric illness: looking through a developmental lens.Evidence-based mental health · 2019Article
- Temperament in child and adolescent offspring of patients with schizophrenia and bipolar disorder.European child & adolescent psychiatry · 2018Article
- The Staging of Major Mood Disorders: Clinical and Neurobiological Correlates.Psychiatry investigation · 2018Article
- Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0.Frontiers in psychiatry · 2018Review
- Methodological considerations regarding Joyce et al. 2016.International journal of bipolar disorders · 2017Article
- Staging in bipolar disorder: from theoretical framework to clinical utility.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2017Article
- Improving outcomes of first-episode psychosis: an overview.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2017Article
- The Lausanne-Geneva cohort study of offspring of parents with mood disorders: methodology, findings, current sample characteristics, and perspectives.Social psychiatry and psychiatric epidemiology · 2017Article
- Bipolar disorder in the digital age: new tools for the same illness.International journal of bipolar disorders · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study is to address the question of whether a universal staging model of severe psychiatric disorders is a viable direction for future research by examining the extant literature.
methodA narrative review was conducted of the relevant historical, conceptual, and empirical literature pertaining to the clinical trajectory of bipolar disorder and schizophrenia and issues relevant to staging.
resultsThere is substantive evidence that classic recurrent bipolar disorder is separable from schizophrenia on the basis of family history, developmental and clinical course, treatment response, and neurobiological findings. However, because of the intrinsic heterogeneity of diagnostic categories that has been amplified by recent changes in psychiatric taxonomy, key distinctions between the groups have become obfuscated. While mapping risk and illness markers to emerging psychopathology is a logical approach and may be of value for some psychiatric disorders and/or their clinical subtypes, robust evidence supporting identifiable stages per se is still lacking. Presently, even rudimentary stages such as prodromes cannot be meaningfully applied across different disorders and no commonalities can be found for the basis of universal staging.
conclusionsAdvances in the prediction of risk, accurate early illness detection, and tailored intervention will require mapping biomarkers and other risk indicators to reliable clinical phases of illness progression. Given the capricious nature of mood and psychotic disorders, this task is likely to yield success only if conducted in narrowly defined subgroups of individuals at high risk for specific illnesses. This approach is diametrically opposite to that being promulgated by proponents of a universal staging model.
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