SynthesisCanadian journal of psychiatry. Revue canadienne de psychiatrie2017
The Age of Onset of Anxiety Disorders.
Synthesis in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
165 citing papers in PubMed, 9 syntheses or guidelines pooled it, 410 citations in OpenAlex.
- Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.Molecular psychiatry · 2026Pooled it
- A review of the 257 meta-analyses of the differences between females and males in prevalence and risk, protective factors, and treatment outcomes for mental disorder.BMC psychiatry · 2025Pooled it
- Panic disorder during pregnancy and the first three years after delivery: a systematic review.BMC pregnancy and childbirth · 2025Pooled it
- Application of Positive Psychology in Digital Interventions for Children, Adolescents, and Young Adults: Systematic Review and Meta-Analysis of Controlled Trials.JMIR mental health · 2024Pooled it
- A systematic review and meta-analysis of studies exploring prevalence of non-specific anxiety in undergraduate university students.BMC psychiatry · 2023Pooled it
- Effectiveness of Social Inclusion Interventions for Anxiety and Depression among Adolescents: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Therapeutic effects of Silexan on somatic symptoms and physical health in patients with anxiety disorders: A meta-analysis.Brain and behavior · 2021Pooled it
- A systematic review on the effect of work-related stressors on mental health of young workers.International archives of occupational and environmental health · 2020Pooled it
- Effectiveness of noninvasive brain stimulation in the treatment of anxiety disorders: a meta-analysis of sham or behaviour-controlled studies.Journal of psychiatry & neuroscience : JPNPooled it
- Group Cognitive Behavioral Therapy With Virtual Reality Exposure Versus In-Vivo Exposure for Social Anxiety Disorder and Agoraphobia: Underpowered Results From the SoREAL Pragmatic Randomized Clinical Trial.JMIR mental health · 2025Trial
- Trial
- The acceptability of a guided internet-based trauma-focused self-help programme (Spring) for post-traumatic stress disorder (PTSD).European journal of psychotraumatology · 2023Trial
- Challenges in Recruiting University Students for Web-Based Indicated Prevention of Depression and Anxiety: Results From a Randomized Controlled Trial (ICare Prevent).Journal of medical Internet research · 2022Trial
- Integrating EEG and fMRI in naturalistic paradigms: Advances in understanding mental disorders-a decade study in review (2014-2024).Dialogues in clinical neuroscience · 2026Review
- Distinct facets of other-oriented social cognition show differential associations with internalizing symptoms in young women with low subjective social status.Journal of mood and anxiety disorders · 2026Article
- Early outdoor play predicts trajectories of child mental health in a population-based cohort.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Preliminary Clinical Outcomes of Culturally Adapted Cognitive Behavioral Therapy for Reducing Panic Disorder Symptoms and Improving Quality of Life: Pilot Study.Behavioral sciences (Basel, Switzerland) · 2026Article
- Is there evidence for additive neurocognitive deficits in adults with attention-deficit/hyperactivity disorder and co-occurring conditions?Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Investigation of polygenic risk scores and subphenotypes in social anxiety disorder.Translational psychiatry · 2026Article
- Deciding "what" to screen for and "when": The importance of natural history information.American journal of human genetics · 2026Review
105 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective was to estimate the age of onset (AOO) for all anxiety disorders and for specific subtypes. Gender differences in the AOO of anxiety disorders were examined, as were the influence of study characteristics on reported AOOs.
methodsSeven electronic databases were searched up to October 2014, with keywords representing anxiety disorder subtypes, AOO, and study design. The inclusion criteria were studies using a general population sample that provided data on the AOO for all anxiety disorders, or specific anxiety disorders, according to DSM-III-R, DSM-IV, or ICD-10 criteria.
resultsThere were 1028 titles examined, which yielded 24 studies meeting the inclusion criteria. Eight studies reported the AOO and gender. Meta-analysis found a mean AOO of all anxiety disorders of 21.3 years (95% CI 17.46 to 25.07). Separation anxiety disorder, specific phobia, and social phobia had their mean onset before the age of 15 years, whereas the AOO of agoraphobia, obsessive-compulsive disorder, posttraumatic stress disorder, panic disorder, and generalized anxiety disorder began, on average, between 21.1 and 34.9 years. Meta-analysis revealed no difference in the AOO between genders. A prospective study design and higher developmental level of the study country were associated with an earlier AOO.
conclusionsResults from this meta-analysis indicate that anxiety disorder subtypes differ in the mean AOO, with onsets ranging from early adolescence to young adulthood. These findings suggest that prevention strategies of anxiety disorders should be directed towards factors associated with the development of anxiety disorder subtypes in the age groups with the greatest vulnerability for developing those disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.