Evidence map›Paper›PMID 27308639›Full record

ArticleOpera medica et physiologica2016

PATHOBIOLOGY OF NEURODEGENERATION: THE ROLE FOR ASTROGLIA.

Alexei Verkhratsky, Robert Zorec, Jose J Rodriguez, Vladimir Parpura

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Opera medica et physiologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Astrocytes in Down Syndrome Across the Lifespan.Frontiers in cellular neuroscience · 2021
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Article
  15. A Compartmental Model to Investigate Local and Global CaFrontiers in computational neuroscience · 2018
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Alexei VerkhratskyFaculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK; University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia; Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain & Department of Neurosciences, University of the Basque Country UPV/EHU and CIBERNED, Leioa, Spain.
Robert ZorecUniversity of Ljubljana, Institute of Pathophysiology, Laboratory of Neuroendocrinology and Molecular Cell Physiology, Zaloska cesta 4; SI-1000, Ljubljana, Slovenia; Celica, BIOMEDICAL, Technology Park 24, 1000 Ljubljana, Slovenia.
Jose J RodriguezAchucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain & Department of Neurosciences, University of the Basque Country UPV/EHU and CIBERNED, Leioa, Spain.
Vladimir ParpuraDepartment of Neurobiology, Civitan International Research Center and Center for Glial Biology in Medicine, Evelyn F. McKnight Brain Institute, Atomic Force Microscopy & Nanotechnology Laboratories, 1719 6th Avenue South, CIRC 429, University of Alabama, Birmingham, AL 35294-0021, USA.
University of the Basque Country · ESUniversity of Alabama at Birmingham · USUniversity of Ljubljana · SI

Funding

The Role of Astroglia in the Enteric Nervous System and Gut FunctionR21HD078678 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PARPURA, VLADIMIR · 2014 to 2015
$400k
NICHD NIH HHS R21 HD078678
6 · The paper itself

Abstract

The common denominator of neurodegenerative diseases, which mainly affect humans, is the progressive death of neural cells resulting in neurological and cognitive deficits. Astroglial cells are the central elements of the homoeostasis, defence and regeneration of the central nervous system, and their malfunction or reactivity contribute to the pathophysiology of neurodegenerative diseases. Pathological remodelling of astroglia in neurodegenerative context is multifaceted. Both astroglial atrophy with a loss of function and astroglial reactivity have been identified in virtually all the forms of neurodegenerative disorders. Astroglia may represent a novel target for therapeutic strategies aimed at preventing and possibly curing neurodegenerative diseases.

Indexed as

Alzheimer’s diseaseAmyotrophic lateral sclerosisAstrogliaHuntington diseaseNeurodegenerative diseasesNeurogliaNeurology

Identifiers

PMID27308639
PMCPMC4905715
OpenAlexW2469173862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.