Evidence map›Paper›PMID 27308638›Full record

ArticleMolecular & cellular oncology2016

Connexin arrests the cell cycle through cytosolic retention of an E3 ligase.

Qian Shi, Jean X Jiang

Open access · bronzeAbstract read
In one paragraph

Article in Molecular & cellular oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Qian ShiDepartments of Biochemistry, University of Texas Health Science Center , 7703 Floyd Curl Drive , San Antonio, TX, USA.
Jean X JiangDepartments of Biochemistry, University of Texas Health Science Center , 7703 Floyd Curl Drive , San Antonio, TX, USA.
The University of Texas Health Science Center at San Antonio · US

Funding

Intercellular Communication in the Eye LensR01EY012085 · NEI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean X Jiang · 2003 to 2026
$8.4M
Connexin hemichannels in suppression of breast cancer bone metastasisR01CA196214 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JIANG, JEAN X, SUN, LUZHE · 2016 to 2020
$1.8M
NCI NIH HHS R01 CA196214NEI NIH HHS R01 EY012085
6 · The paper itself

Abstract

The gap junction proteins connexins play important roles in cell growth and differentiation; however, the underlying mechanism remains largely elusive. We recently identified a channel-independent role of connexins in cell cycle control in which connexin 50 directly interacts with S-phase kinase 2 and prevents its nuclear localization, resulting in p27/p57 protection and cell cycle arrest.

Indexed as

Cell cycleconnexinE3 ligase Skp2lens cells

Identifiers

PMID27308638
PMCPMC4905427
OpenAlexW2321411422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.