Evidence map›Paper›PMID 27308618›Full record

ArticleMolecular & cellular oncology2016

Chewing the fat for Akt1 inhibition and oncosuppression.

Sara M Nowinski, Ashley Solmonson, Edward M Mills

Abstract read
In one paragraph

Article in Molecular & cellular oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sara M NowinskiDepartment of Biochemistry, University of Utah School of Medicine , Salt Lake City, UT, USA.
Ashley SolmonsonDivision of Pharmacology and Toxicology, College of Pharmacy and; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA.
Edward M MillsDivision of Pharmacology and Toxicology, College of Pharmacy and; Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA.

Funding

Interdisciplinary Training Program in MetabolismT32DK091317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI SCOTT A SUMMERS · 2011 to 2026
$4.8M
Molecular mechanisms of thermogenesisR01DK089224 · NIDDK · UNIVERSITY OF TEXAS AT AUSTIN · PI DIGIOVANNI, JOHN · 2011 to 2023
$3.4M
Molecular mechanisms of thermogenesisR56DK089224 · NIDDK · UNIVERSITY OF TEXAS AT AUSTIN · PI MILLS, EDWARD M · 2017 to 2017
$229k
NIDDK NIH HHS R01 DK089224NIDDK NIH HHS R56 DK089224NIDDK NIH HHS T32 DK091317
6 · The paper itself

Abstract

The catabolic and energy-dissipating actions of mitochondrial uncoupling proteins (UCPs) conflict with many of the bioenergetic hallmarks of malignancy. We have recently demonstrated that overexpression of mitochondrial uncoupling protein 3 (Ucp3) in the basal epidermis impedes skin tumorigenesis through a novel pathway of thymoma viral proto-oncogene 1 (Akt1) inhibition via increased mitochondrial lipid catabolism.

Indexed as

Aktkeratinocyteslipid catabolismmetabolomicsmitochondriaskin cancerUCP3uncouplinguncoupling proteins

Identifiers

PMID27308618
PMCPMC4905408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.