ArticleMolecular & cellular oncology2016
Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia.
Article in Molecular & cellular oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Elevated Acetylation of MFN2 is Accompanied by the Disruption of Mitochondrial Energy Metabolism and Inflammation in a Mouse Model of Depression.Molecular neurobiology · 2025Article
- Resveratrol activation of SIRT1/MFN2 can improve mitochondria function, alleviating doxorubicin-induced myocardial injury.Cancer innovation · 2023Article
- Impaired mitochondrial dynamics and removal of the damaged mitochondria in diabetic retinopathy.Frontiers in endocrinology · 2023Article
- Inclusion Body Myositis and Neoplasia: A Narrative Review.International journal of molecular sciences · 2022Review
- Alterations in mitochondrial dynamics with age-related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility.Aging cell · 2021Article
- Mitochondrial Content, but Not Function, Is Altered With a Multimodal Resistance Training Protocol and Adequate Protein Intake in Leucine-Supplemented Pre/Frail Women.Frontiers in nutrition · 2020Article
- Dietary Melatonin Supplementation Could Be a Promising Preventing/Therapeutic Approach for a Variety of Liver Diseases.Nutrients · 2018Review
- Yap regulates gastric cancer survival and migration via SIRT1/Mfn2/mitophagy.Oncology reports · 2018Article
- Mitochondria Initiate and Regulate Sarcopenia.Exercise and sport sciences reviews · 2017Review
- Mitochondrial-Shaping Proteins in Cardiac Health and Disease - the Long and the Short of It!Cardiovascular drugs and therapy · 2017Review
- Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.Nature communications · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.