Evidence map›Paper›PMID 27308502›Full record

ArticleMolecular & cellular oncology

Autophagy, a double-edged sword in hepatocarcinogenesis.

Yongjun Tian, Linya Wang, Jing-Hsiung James Ou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Fluid Shear Stress Promotes Autophagy in Hepatocellular Carcinoma Cells.International journal of biological sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yongjun TianDepartment of Molecular Microbiology and Immunology; University of Southern California Keck School of Medicine ; Los Angeles, CA, USA.
Linya WangDepartment of Molecular Microbiology and Immunology; University of Southern California Keck School of Medicine ; Los Angeles, CA, USA.
Jing-Hsiung James OuDepartment of Molecular Microbiology and Immunology; University of Southern California Keck School of Medicine ; Los Angeles, CA, USA.
University of Southern California · US

Funding

HBV replication and carcinogenesisR01CA177337 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OU, J.-H. JAMES · 2013 to 2015
$583k
NCI NIH HHS R01 CA177337
6 · The paper itself

Abstract

Autophagy has opposite effects on hepatocarcinogenesis depending on whether it occurs before or after its onset. Autophagy prevents the initiation of hepatocarcinogenesis by suppressing oxidative stress and DNA damage. However, it also inhibits cell death and the expression of tumor suppressors to promote tumor progression once hepatocarcinogenesis has been initiated.

Indexed as

autophagyhepatocarcinogenesisoxidative stresstumor progressiontumor suppressors

Identifiers

PMID27308502
PMCPMC4905348
OpenAlexW1527130030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.