Evidence map›Paper›PMID 27308464›Full record

ArticleMolecular & cellular oncology

Flicking the molecular switch underlying MLKL-mediated necroptosis.

Joanne M Hildebrand, Isabelle S Lucet, James M Murphy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Joanne M HildebrandCell Signalling and Cell Death Division; The Walter and Eliza Hall Institute of Medical Research; Parkville, Australia; Department of Medical Biology; University of Melbourne; Parkville, Victoria, Australia.
Isabelle S LucetDepartment of Medical Biology; University of Melbourne; Parkville, Victoria, Australia; ACRF Chemical Biology Division; The Walter and Eliza Hall Institute of Medical Research; Parkville, Australia.
James M MurphyCell Signalling and Cell Death Division; The Walter and Eliza Hall Institute of Medical Research; Parkville, Australia; Department of Medical Biology; University of Melbourne; Parkville, Victoria, Australia.
Walter and Eliza Hall Institute of Medical Research · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited by an ATP-mimetic small molecule that binds the pseudokinase domain of MLKL.

Identifiers

PMID27308464
PMCPMC4905300
OpenAlexW2086102862

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.