Evidence map›Paper›PMID 27308375›Full record

ArticleMolecular & cellular oncology

Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade.

Katharina Schulenburg, Gabor Glatz, Attila Remenyi, Krishnaraj Rajalingam

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 5 countries.

Katharina SchulenburgCell Death Signaling Group; Institute of Biochemistry II; Goethe University Medical School ; Frankfurt, Germany.
Gabor GlatzDepartment of Biochemistry; Eötvös Loránd University; Budapest; Hungary Institute of Enzymology; Research Center for Natural Sciences Hungarian Academy of Sciences ; Budapest, Hungary.
Attila RemenyiDepartment of Biochemistry; Eötvös Loránd University; Budapest; Hungary Institute of Enzymology; Research Center for Natural Sciences Hungarian Academy of Sciences ; Budapest, Hungary.
Krishnaraj RajalingamCell Death Signaling Group; Institute of Biochemistry II; Goethe University Medical School; Frankfurt, Germany; FZI; Molecular Signaling Unit; Institute for immunology; University Medical Center of the Johannes Gutenberg-University Mainz; Mainz, Germany.
Eötvös Loránd University · HUGoethe University Frankfurt · DEInstitute of Molecular Life Sciences · HUToxicologie, Pharmacologie et Signalisation Cellulaire · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, we revealed that ubiquitination of MEKK2 and MEKK3 by inhibitor of apoptosis proteins (IAPs) directly disrupts MEK5/ERK5 interaction and subsequently attenuates ERK5 activation. In addition, loss of XIAP promotes human myogenic differentiation in an ERK5-dependent manner. These results reveal another layer of MAPK regulation and a novel role for XIAP in controlling myogenic differentiation.

Indexed as

cIAP1ERK5IAPMAPKPB1ubiquitinXIAP

Identifiers

PMID27308375
PMCPMC4905217
OpenAlexW2045279963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.