Evidence map›Paper›PMID 27308355›Full record

ArticleMolecular & cellular oncology

Targeting the sumoylation pathway in cancer stem cells.

Maria V Bogachek, James P De Andrade, Ronald J Weigel

Abstract read
In one paragraph

Article in Molecular & cellular oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria V BogachekDepartment of Surgery; University of Iowa ; Iowa City, IA USA.
James P De AndradeDepartment of Surgery; University of Iowa ; Iowa City, IA USA.
Ronald J WeigelDepartment of Surgery; University of Iowa; Iowa City, IA USA; Department of Anatomy and Cell Biology; University of Iowa; Iowa City, IA USA; Department of Biochemistry; University of Iowa; Iowa City, IA USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSCs) represent a subset of tumor cells with tumor-initiating potential. We recently demonstrated that inhibition of the sumoylation pathway cleared the CSC population and repressed the outgrowth of basal breast cancer xenografts. Targeting the sumoylation pathway offers a novel treatment strategy for basal breast cancer.

Indexed as

basal breast cancercancer stem cellsCD44epithelial-mesenchymal transitionSUMOsumoylationTFAP2A

Identifiers

PMID27308355
PMCPMC4905063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.