ArticleJournal of arthropod-borne diseases2016
Genetic Diversity of Crimean Congo Hemorrhagic Fever Virus Strains from Iran.
Article in Journal of arthropod-borne diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Epidemiological patterns of Crimean-Congo hemorrhagic fever in Iran and its neighboring endemic high-risk territories: A systematic review.Parasite epidemiology and control · 2026Review
- Genetic features of Orthonairovirus haemorrhagiae variants detected in ixodid ticks in Armenia.PLoS neglected tropical diseases · 2025Article
- Genetic evidence of regional circulation of Crimean-Congo hemorrhagic fever virus in ixodid ticks from southern Kazakhstan.Frontiers in veterinary science · 2025Article
- Medically Significant Vector-Borne Viral Diseases in Iran.Microorganisms · 2023Review
- Host response transcriptomic analysis of Crimean-Congo hemorrhagic fever pathogenesis in the cynomolgus macaque model.Scientific reports · 2021Article
- Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe.Microorganisms · 2021Review
- Aptamer based diagnosis of crimean-congo hemorrhagic fever from clinical specimens.Scientific reports · 2021Article
- Genetic diversity and phylogenetic analysis of Crimean-Congo Hemorrhagic Fever viruses circulating in Pakistan during 2019.PLoS neglected tropical diseases · 2020Article
- Evaluation of Crimean-Congo Hemorrhagic Fever Orthonairovirus AviTagged Nucleoprotein for Potential Application in DiagnosisIranian biomedical journal · 2019Article
- Clinical and molecular epidemiology of Crimean-Congo hemorrhagic fever in Oman.PLoS neglected tropical diseases · 2019Article
- Diagnostic tests for Crimean-Congo haemorrhagic fever: a widespread tickborne disease.BMJ global health · 2019Article
- Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang, China.Virologica Sinica · 2018Article
- Co-circulation of Crimean-Congo Hemorrhagic Fever virus strains Asia 1 and 2 between the border of Iran and Pakistan.Heliyon · 2017Article
- Emerging and re-emerging infectious diseases in Iran.Iranian journal of microbiology · 2017Review
- Current status of Crimean-Congo haemorrhagic fever in the World Health Organization Eastern Mediterranean Region: issues, challenges, and future directions.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2017Review
- Crimean-Congo hemorrhagic fever cases in the North of Iran have three distinct origins.Virusdisease · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCrimean Congo hemorrhagic fever virus (CCHFV) is a member of the Bunyaviridae family and Nairovirus genus. It has a negative-sense, single stranded RNA genome approximately 19.2 kb, containing the Small, Medium, and Large segments. CCHFVs are relatively divergent in their genome sequence and grouped in seven distinct clades based on S-segment sequence analysis and six clades based on M-segment sequences. Our aim was to obtain new insights into the molecular epidemiology of CCHFV in Iran.
methodsWe analyzed partial and complete nucleotide sequences of the S and M segments derived from 50 Iranian patients. The extracted RNA was amplified using one-step RT-PCR and then sequenced. The sequences were analyzed using Mega5 software.
resultsPhylogenetic analysis of partial S segment sequences demonstrated that clade IV-(Asia 1), clade IV-(Asia 2) and clade V-(Europe) accounted for 80 %, 4 % and 14 % of the circulating genomic variants of CCHFV in Iran respectively. However, one of the Iranian strains (Iran-Kerman/22) was associated with none of other sequences and formed a new clade (VII). The phylogenetic analysis of complete S-segment nucleotide sequences from selected Iranian CCHFV strains complemented with representative strains from GenBank revealed similar topology as partial sequences with eight major clusters. A partial M segment phylogeny positioned the Iranian strains in either association with clade III (Asia-Africa) or clade V (Europe).
conclusionThe phylogenetic analysis revealed subtle links between distant geographic locations, which we propose might originate either from international livestock trade or from long-distance carriage of CCHFV by infected ticks via bird migration.
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27308271PMC4906752W2209772731What OpenQuestion holds
Registered trials
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