ArticleIranian journal of pediatrics2016
Comparison of Complications and Efficacy of NIPPV and Nasal CPAP in Preterm Infants With RDS.
Article in Iranian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Non-invasive respiratory support in preterm infants as primary mode: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Comparative effectiveness of nasal intermittent positive pressure ventilation vs continuous positive airway pressure in preterm infants with RDS: an updated systematic review and meta-analysis of randomized controlled trials.European journal of pediatrics · 2025Pooled it
- Efficacy and safety of different noninvasive ventilation strategies for postextubation respiratory support in Neonatal Respiratory Distress Syndrome: a systematic review and network meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Predictors and outcomes of successful primary nasal intermittent positive pressure ventilation in extremely preterm infants: A retrospective observational study.Qatar medical journal · 2025Trial
- Nasal Trauma Among Neonatal Intensive Care Unit Patients: A Retrospective Single Center Experience.Pediatric health, medicine and therapeutics · 2025Article
- Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation.The Cochrane database of systematic reviews · 2023Review
- Early nasal intermittent positive pressure ventilation (NIPPV) versus early nasal continuous positive airway pressure (NCPAP) for preterm infants.The Cochrane database of systematic reviews · 2023Review
- Non-Invasive Ventilatory Strategies to Decrease Bronchopulmonary Dysplasia-Where Are We in 2021?Children (Basel, Switzerland) · 2021Review
- Practical aspects on the use of non-invasive respiratory support in preterm infants.International journal of pediatrics & adolescent medicine · 2020Review
- Non-invasive Respiratory Support of the Premature Neonate: From Physics to Bench to Practice.Frontiers in pediatrics · 2020Review
- Current insights in non-invasive ventilation for the treatment of neonatal respiratory disease.Italian journal of pediatrics · 2019Review
- Heated Humidified High Flow Nasal Cannula (HHHFNC) is not an effective method for initial treatment of Respiratory Distress Syndrome (RDS) versus nasal intermittent mandatory ventilation (NIMV) and nasal continuous positive airway pressure (NCPAP).Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Article
- [Research advances in neonatal nasal intermittent positive pressure ventilation].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory distress syndrome (RDS) is one of the most common diseases in neonates admitted to NICU. For this important cause of morbidity and mortality in preterm neonates, several treatment methods have been used. To date, non-invasive methods are preferred due to fewer complications.
objectivesHerein, two non-invasive methods of ventilation support are compared: NCPAP vs. NIPPV. PATIENTS AND
methodsThis is a randomized clinical trial. Premature neonates with less than 34 weeks gestation, suffering from RDS entered the study, including 151 newborns admitted to Vali-Asr NICU during 2012-2013. Most of these patients received surfactant as early rescue via INSURE method and then randomly divided into two NCPAP (73 neonates) and NIPPV (78 neonates) groups. Both early and late complications are compared including extubation failure, hospital length of stay, GI perforation, apnea, intraventricular hemorrhage (IVH) and mortality rate.
resultsThe need for re-intubation was 6% in NIPPV vs. 17.6% in NCPAP group, which was statistically significant (P = 0.031). The length of hospital stay was 23.92 ± 13.5 vs. 32.61 ± 21.07 days in NIPPV and NCPAP groups, respectively (P = 0.002). Chronic lung disease (CLD) was reported to be 4% in NCPAP and 0% in NIPPV groups (P = 0.035). The most common complication occurred in both groups was traumatization of nasal skin and mucosa, all of which fully recovered. Gastrointestinal perforation was not reported in either group.
conclusionsThis study reveals the hospital length of stay, re-intubation and BPD rates are significantly declined in neonates receiving NIPPV as the treatment for RDS.
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