ArticleBasic and clinical neuroscience2015
Antiamnesic Effects of Walnuts Consumption on Scopolamine-Induced Memory Impairments in Rats.
Article in Basic and clinical neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Role of the NLRP3 inflammasome in diabetes and its complications (Review).Molecular medicine reports · 2025Review
- Manasamitra Vatakam on Scopolamine-Induced Amnesia in Female Wistar Rats.Journal of pharmacy & bioallied sciences · 2024Article
- Neuroprotective effects of walnutIranian journal of basic medical sciences · 2024Review
- The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction.Metabolic brain disease · 2023Article
- Antiamnesic and Neuroprotective Effects of an Aqueous Extract ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Article
- Ameliorating Effect of Standardized Extract From Textured Soy Protein (Basic and clinical neuroscienceArticle
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlzheimer's disease (AD) is an age-related neurodegenerative disease, which impairs memory and cognitive function. Walnuts are a dietary source of polyphenols, antioxidants and other compounds with health beneficial effects. These characteristic of walnuts make them perfect candidates for evaluation of their possible effects on neurodegenerative diseases. Therefore the present study was designed to investigate the effects of walnuts consumption (2%, 6% and 9% walnut diets) on memory enhancement and acetylcholinesterase (AChE) activity of brain in scopolamine-induced amnesic rats.
methodsLearning, memory and locomotor activity parameters were evaluated using Morris water maze (MWM), passive avoidance and rotarod tests.
resultsOur results showed that consumption of walnuts at doses of 6% and 9% significantly restored the scopolamine-induced memory impairments in the MWM and passive avoidance tests. Moreover, the potential of walnuts to prevent scopolamine neurotoxicity was also reflected by the decreased AChE activity in the whole brain in comparison with the scopolamine group. DISCUSSION: These results suggest that walnuts may be useful against memory impairment and it may exert these anti-amnesic activities via inhibition of AChE activity in the brain. It would be worthwhile to explore the potential of this nut and its active components in the management of the AD.
Indexed as
Identifiers
27307953PMC4636883What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.