ArticleThe EPMA journal2016
Multiple sclerosis and primary vascular dysregulation (Flammer syndrome).
Article in The EPMA journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- A ginger extract improves ocular blood flow in rats with endothelin-induced retinal blood flow dysfunction.Scientific reports · 2023Article
- Choroidal Thickness in Multiple Sclerosis: An Optical Coherence Tomography Study.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Health screening program revealed risk factors associated with development and progression of papillomacular bundle defect.The EPMA journal · 2021Article
- Flammer syndrome in multiple sclerosis: diagnostics, prediction, and personalization of treatments.The EPMA journal · 2019Article
- Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach.The EPMA journal · 2019Review
- Transient visual field impairment after cold provocation in glaucoma patients with Flammer syndrome.Restorative neurology and neuroscience · 2019Article
- Mental stress as consequence and cause of vision loss: the dawn of psychosomatic ophthalmology for preventive and personalized medicine.The EPMA journal · 2018Review
- The definition and diagnosis of cold hypersensitivity in the hands and feet: Finding from the experts survey.Integrative medicine research · 2018Article
- Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness - a review.Restorative neurology and neuroscience · 2018Review
- Diseases potentially related to Flammer syndrome.The EPMA journal · 2017Review
- The potential relationship between Flammer and Sjögren syndromes: the chime of dysfunction.The EPMA journal · 2017Review
- Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system.The EPMA journal · 2017Review
- Postmenopausal breast cancer: European challenge and innovative concepts.The EPMA journal · 2017Article
- Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach?The EPMA journal · 2017Article
- The discovery of the Flammer syndrome: a historical and personal perspective.The EPMA journal · 2017Review
- Traditional medicine as a potential treatment for Flammer syndrome.The EPMA journal · 2017Article
- "Pre-metastatic niches" in breast cancer: are they created by or prior to the tumour onset? "Flammer Syndrome" relevance to address the question.The EPMA journal · 2017Article
- Relationship between normal tension glaucoma and Flammer syndrome.The EPMA journal · 2017Article
- Association of vitamin D status and clinical and radiological outcomes in a treated MS population in Poland.Brain and behavior · 2017Article
- Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016.The EPMA journal · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS of still unknown aetiology. Flammer syndrome (FS) encompasses a set of symptoms and signs that are primarily but not solely related to the dysregulation of blood vessels. The purpose of the present study was to determine whether FS symptoms occur more often in MS patients than in controls.
methodsFifty-eight MS patients and 259 controls answered a questionnaire covering 15 symptoms and signs of FS.
resultsSix of the 15 symptoms and signs of FS (dizziness, low body mass index, cold hands and/or feet, tendency toward perfectionism, reduced thirst, feeling cold) were found significantly more often in MS patients than in controls. Seven additional symptoms and signs (tinnitus, headaches, increased pain sensation, long sleep-onset time, migraines, increased response to certain drugs, low blood pressure) also occurred more often in MS patients, but the difference in frequency was not statistically significant. One sign (reversible skin blotches) was found less often in MS patients, but the difference in frequency was not statistically significant. One symptom (increased smell perception) was found significantly less often in MS patients.
conclusionsMS patients suffer significantly more often from FS symptoms and signs than controls. The reason for this association between MS and FS and the potential implications of this association still need to be determined.
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