ArticleInternational journal of nanomedicine2016
Silica nanoparticles induce reversible damage of spermatogenic cells via RIPK1 signal pathways in C57 mice.
Article in International journal of nanomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Assessment of Gold-Mediated Male Reproductive Dysfunction in Male WISTAR Rats Through Sperm Analysis and Testosterone Measurement.Journal of applied toxicology : JAT · 2026Article
- Multi-omics analysis of testis after long-term exposure to polystyrene nanoplastics reveals premature testicular aging and age-dependent damage in mice.Particle and fibre toxicology · 2025Article
- Reproductive Toxicity of Nanoparticles: A Comprehensive Review.Current medicinal chemistry · 2025Review
- Nanomaterial-Driven Regulated Cell Death: Mechanistic Insights and Novel Strategies for Tumor Therapy.International journal of nanomedicine · 2025Review
- Assessment of reproductive toxicity of gold nanoparticles and its reversibility in male albino rats.Toxicological research · 2024Article
- Fluorescent nanodiamond labels: Size and concentration matters for sperm cell viability.Materials today. Bio · 2023Article
- Cytotoxic effects of dose dependent inorganic magnesium oxide nanoparticles on the reproductive organs of rats.Annals of medicine · 2023Article
- Article
- Activation of Autophagy by Low-Dose Silica Nanoparticles Enhances Testosterone Secretion in Leydig Cells.International journal of molecular sciences · 2022Article
- Attributes of oxidative stress in the reproductive toxicity of nickel oxide nanoparticles in male rats.Environmental science and pollution research international · 2022Article
- The effect of SiNPs on DNA methylation of genome in mouse spermatocytes.Environmental science and pollution research international · 2021Article
- Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis.Environmental science and pollution research international · 2020Review
- Silica nanoparticles induce unfolded protein reaction mediated apoptosis in spermatocyte cells.Toxicology research · 2020Article
- Lipid-coated ZnO nanoparticles synthesis, characterization and cytotoxicity studies in cancer cell.Nano convergence · 2020Article
- LaInternational journal of nanomedicine · 2020Article
- Combined Subchronic Toxicity of Aluminum (III), Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors.International journal of molecular sciences · 2018Article
- Pulmonary exposure to carbonaceous nanomaterials and sperm quality.Particle and fibre toxicology · 2018Article
- Potential adverse effects of nanoparticles on the reproductive system.International journal of nanomedicine · 2018Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reproductive toxicity of silica nanoparticles (SiNPs) is well known, but the underlying mechanism is still not clear. To investigate the toxic mechanism of SiNPs on spermatogenic cells, 60 C57 male mice were randomly and equally divided into three groups (the control group, the saline control group, and the SiNPs group) with two observed time points (45 days and 75 days). The mice in the SiNPs group were administered with SiNPs 2 mg/kg diluted in normal saline, and the mice of the saline control group were given equivoluminal normal saline by tracheal perfusion every 3 days for 45 days (in total 15 times). The control group mice were bred without treatment. In each group, a half number of the mice were sacrificed on the 45th day after the first dose, and the remaining half were sacrificed on the 75th day. The results showed that SiNPs increased the malformation of sperms and decreased the motility and concentration of sperms in epididymis on the 45th day after the first dose. SiNPs induced oxidative stress in testis and led to apoptosis and necroptosis of the spermatogenic cells. Furthermore, SiNPs increased the expression of Fas/FasL/RIPK1/FADD/caspase-8/caspase-3 and RIPK3/MLKL on the 45th day after the first dose. However, compared with the saline control group, the index of sperms and the expression of Fas/FasL/RIPK1/FADD/caspase-8/caspase-3/RIPK3/MLKL showed no significant changes in the SiNPs group on the 75th day after the first dose. These data suggested that SiNPs could induce apoptosis and necroptosis in the spermatogenic cells by activating the RIPK1 pathway resulting from oxidative stress in male mice. SiNPs-induced damage recovered on the 75th day after the first dose, which suggested that SiNPs-induced toxicity is reversible.
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