ArticleContemporary clinical dentistry
Evaluation of salivary interleukin-6 in children with early childhood caries after treatment.
Article in Contemporary clinical dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Role of Immunological Markers in Diagnosis, Prognosis, and Treatment of Early Childhood Caries and Adult Caries: A Systematic Review.International journal of clinical pediatric dentistry · 2026Article
- Salivary Interleukin-6 and Tumor Necrosis Factor-α changes following total oral rehabilitation in children with mild intellectual disability: a prospective interventional study.BMC oral health · 2026Article
- Salivary proteins, proteases, and disease pathophysiology in oral health and precision diagnostics: a narrative review.Frontiers in dental medicine · 2026Review
- Pre-post intervention changes in salivary biomarkers after dental treatment in children with caries: A systematic review and meta-analysis.Journal of clinical and experimental dentistry · 2025Review
- Salivary IL-6 as a Biomarker for Early Childhood and Rampant Caries: Insights from a Cross-Sectional Study.Biomedicines · 2025Article
- Selected Saliva-Derived Cytokines and Growth Factors Are Elevated in Pediatric Dentofacial Inflammation.International journal of molecular sciences · 2024Article
- Saliva-Based Protein Analysis in Pediatric Dentofacial Inflammation.Pediatric health, medicine and therapeutics · 2024Article
- Associations between salivary cytokines and oral health, age, and sex in healthy children.Scientific reports · 2022Article
- Human Saliva as a Diagnostic Specimen for Early Detection of Inflammatory Biomarkers by Real-Time RT-PCR.Inflammation · 2021Review
- Correlation of s-IgA and IL-6 Salivary with Caries Disease and Oral Hygiene Parameters in Children.Dentistry journal · 2019Article
- Salivary Protein Roles in Oral Health and as Predictors of Caries Risk.Open life sciences · 2018Article
- Efficacy of a Calcium Sucrose Phosphate Based Toothpaste in Elevating the Level of Calcium, Phosphate Ions in Saliva and Reducing Plaque: A Clinical Trial.Contemporary clinical dentistryArticle
- Association between Salivary Cortisol, Secretory IgA, and Inflammatory Cytokines with Early Childhood Caries: A Cross-sectional Analytical Study.Journal of International Society of Preventive & Community DentistryArticle
- Assessment of Salivary Flow Rate and Antioxidant Levels in Ectodermal Dysplasia Patients: AnContemporary clinical dentistryArticle
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7 authors.
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Abstract
backgroundThe role of cytokines as a marker in the oral inflammatory process in ECC has not been fully explored before and after full mouth rehabilitation.
aimsThe aim of this study was to assess the level of salivary interleukin-6 (IL-6) in children with ECC and to compare its levels before and after comprehensive full mouth rehabilitation. METHODS AND MATERIALS: Saliva samples were collected from children with ECC prior to dental treatment and 3-month post treatment. The salivary IL-6 levels were analyzed using the ELISA method. The gingival index was also timely recorded. Oral health awareness sessions were conducted for children and their parents at regular intervals during the 3-month study period. STATISTICAL ANALYSIS USED: Wilcoxon Signed Rank test compared the levels of salivary IL-6 while, the paired t test compared the values of gingival index before and after treatment.
resultsThe mean level of salivary IL-6 before and 3 months after treatment had reduced and this reduction was statistically significant (P < 0.000). The gingival index scores had also reduced significantly 3-months post treatment (P < 0.002).
conclusionsChildren with ECC when completely rehabilitated and kept under frequent follow up, which includes reinforcement of oral hygiene measures and maintaining a low caries activity state, the level of inflammation (IL-6) can definitely be minimized and thereby improving the quality of life of affected children.
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