ArticleJournal of the Royal Society, Interface2016
The cellular Ising model: a framework for phase transitions in multicellular environments.
Article in Journal of the Royal Society, Interface, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Bifurcations and phase transitions in the origins of life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Physical communication pathways in bacteria: an extra layer to quorum sensing.Biophysical reviews · 2025Review
- Stress sharing as cognitive glue for collective intelligences: A computational model of stress as a coordinator for morphogenesis.Biochemical and biophysical research communications · 2024Article
- Fundamental constraints to the logic of living systems.Interface focus · 2024Review
- Reducing herbivory in mixed planting by genomic prediction of neighbor effects in the field.Nature communications · 2024Article
- Emergent order in epithelial sheets by interplay of cell divisions and cell fate regulation.PLoS computational biology · 2024Article
- Spatial biology of Ising-like synthetic genetic networks.BMC biology · 2023Article
- The Role of Experimental Noise in a Hybrid Classical-Molecular Computer to Solve Combinatorial Optimization Problems.ACS central science · 2023Article
- Relevant Analytic Spontaneous Magnetization Relation for the Face-Centered-Cubic Ising Lattice.Entropy (Basel, Switzerland) · 2023Article
- Modeling cancer immunoediting in tumor microenvironment with system characterization through the ising-model Hamiltonian.BMC bioinformatics · 2022Article
- Influencing dynamics on social networks without knowledge of network microstructure.Journal of the Royal Society, Interface · 2021Article
- Dynamical Ising model of spatially coupled ecological oscillators.Journal of the Royal Society, Interface · 2020Article
- Controlling spatiotemporal pattern formation in a concentration gradient with a synthetic toggle switch.Molecular systems biology · 2020Article
- The Affective Ising Model: A computational account of human affect dynamics.PLoS computational biology · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inspired by the Ising model, we introduce a gene regulatory network that induces a phase transition that coordinates robustly the behaviour of cell ensembles. The building blocks of the design are the so-called toggle switch interfaced with two quorum sensing modules, Las and Lux. We show that as a function of the transport rate of signalling molecules across the cell membrane the population undergoes a spontaneous symmetry breaking from cells individually switching their phenotypes to a global collective phenotypic organization. By characterizing the critical behaviour, we reveal some properties, such as phenotypic memory and hypersensitivity, with relevance in the field of synthetic biology. We argue that our results can be extrapolated to other multicellular systems and be a generic framework for collective decision-making processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.