ArticleJournal of psychopharmacology (Oxford, England)2016
Lithium intoxication: Incidence, clinical course and renal function - a population-based retrospective cohort study.
Article in Journal of psychopharmacology (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Towards a Safe and Effective Lithium Therapeutic Range for Older Adults With Bipolar Disorder: An ISBD Task Force Systematic Review.Bipolar disorders · 2026Pooled it
- [S3 guideline on renal replacement therapy in intensive care medicine : Evidence-based implementation of renal replacement therapy in critically ill patients].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Guideline
- Psychotropic Drugs and Adverse Kidney Effects: A Systematic Review of the Past Decade of Research.CNS drugs · 2022Pooled it
- Mental health and kidney disease.Nature reviews. Nephrology · 2026Review
- Early health economic assessment of eLiActa neuropsychiatrica · 2026Article
- Article
- Kidney function decline improves after lithium discontinuation.Journal of internal medicine · 2025Article
- The Application of Deep Brain Stimulation in the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity.Journal of movement disorders · 2025Article
- Medium cut-off membrane expanded hemodialysis for Lithium removal: a case report.Frontiers in toxicology · 2025Article
- Article
- Assessment of the pattern, severity, and outcomes of acute mood stabilizer drug poisoning.Toxicology research · 2024Article
- Lithium: current state of the art and future directions.International journal of bipolar disorders · 2024Review
- Developmental Toxicity and Apoptosis in Zebrafish: The Impact of Lithium Hexafluorophosphate (LiPFInternational journal of molecular sciences · 2024Article
- Lithium: how low can you go?International journal of bipolar disorders · 2024Article
- Editorial: Medical emergencies in psychiatry.Frontiers in psychiatry · 2024Article
- Serious adverse drug events associated with psychotropic treatment of bipolar or schizoaffective disorder: a 17-year follow-up on the LiSIE retrospective cohort study.Frontiers in psychiatry · 2024Article
- Chronic Lithium Toxicity in Old Age Patients Taking Angiotensin Receptor Blocker: A Case Report.JNMA; journal of the Nepal Medical Association · 2023Article
- Sex differences in the cardiac stress response following SARS-CoV-2 infection of ferrets.American journal of physiology. Heart and circulatory physiology · 2023Article
- Lithium poisoning and renal replacement therapy: pathophysiology and current clinical recommendations.International urology and nephrology · 2023Review
- Reimagining safe lithium applications in the living environment and its impacts on human, animal, and plant system.Environmental science and ecotechnology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When prescribing lithium, the risk of toxicity remains a concern. In this study, we examined a cohort of patients exposed to lithium between 1997 and 2013. The aims of this study were to determine the frequency of lithium intoxication and to evaluate the clinical course and changes in renal function. Of 1340 patients, 96 had experienced at least one episode of lithium levels ⩾1.5 mmol/L, yielding an incidence of 0.01 per patient-year. Seventy-seven patients available for review had experienced 91 episodes, of whom 34% required intensive care and 13% were treated with haemodialysis. There were no fatalities. Acute kidney injury occurred, but renal function at baseline was not different to renal function after the episode. Renal impairment was often associated with co-morbidities and other factors. Both intermittent and continuous-venovenous haemodialysis were used, but the clearance of continuous-venovenous haemodialysis can be too low in cases where large amounts of lithium have been ingested. Saline and forced diuresis have been used and are safe. Lithium intoxication seems rare and can be safely managed in most cases. Physicians should not withhold lithium for fear of intoxication in patients who benefit from it. Yet, physicians should have a low threshold to screen for toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.