Evidence map›Paper›PMID 27307143›Full record

SynthesisAmerican journal of Alzheimer's disease and other dementias2016

Cognitive Reserve in Healthy Aging and Alzheimer's Disease: A Meta-Analysis of fMRI Studies.

Stefano Colangeli, Maddalena Boccia, Paola Verde, Paola Guariglia, Filippo Bianchini, Laura Piccardi

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of Alzheimer's disease and other dementias, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Electroencephalography, Magnetoencephalography, and Cognitive Reserve: A Systematic Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stefano ColangeliDepartment of Psychology, "Sapienza" University of Rome, Rome, Italy.
Maddalena BocciaDepartment of Psychology, "Sapienza" University of Rome, Rome, Italy Neuropsychology Unit, IRCCS Fondazione Santa Lucia of Rome, Rome, Italy maddalena.boccia@uniroma1.it.
Paola VerdeItalian Air Force Experimental Flight Center, Aerospace Medicine Department, Pratica di Mare, Rome, Italy.
Paola GuarigliaDipartimento Scienze dell'Uomo e della Società, Università degli Studi Kore Enna, Enna, Italy.
Filippo BianchiniDepartment of Psychology, "Sapienza" University of Rome, Rome, Italy.
Laura PiccardiNeuropsychology Unit, IRCCS Fondazione Santa Lucia of Rome, Rome, Italy Department of Life, Health and Environmental Sciences, L'Aquila University, L'Aquila, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive reserve (CR) has been defined as the ability to optimize or maximize performance through differential recruitment of brain networks. In the present study, we aimed at providing evidence for a consistent brain network underpinning CR in healthy and pathological aging. To pursue this aim, we performed a coordinate-based meta-analysis of 17 functional magnetic resonance imaging studies on CR proxies in healthy aging, Alzheimer's disease (AD), and mild cognitive impairment (MCI). We found that different brain areas were associated with CR proxies in healthy and pathological aging. A wide network of areas, including medial and lateral frontal areas, that is, anterior cingulate cortex and dorsolateral prefrontal cortex, as well as precuneus, was associated with proxies of CR in healthy elderly patients. The CR proxies in patients with AD and amnesic-MCI were associated with activation in the anterior cingulate cortex. These results were discussed hypothesizing the existence of possible compensatory mechanisms in healthy and pathological aging.

Indexed as

AgingAlzheimer DiseaseCognitive DysfunctionCognitive ReserveHumansMagnetic Resonance ImagingAlzheimer’s diseasebrain maintenancebrain reservefMRImild cognitive impairment

Identifiers

PMID27307143
PMCPMC10852844

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.